The specter of peri-procedural stroke looms large over transcarotid transcatheter aortic valve replacement (TCAR TAVR). While advancements in technique and technology have mitigated some of this risk, real-time monitoring of cerebral perfusion remains a challenge. A recent case report suggests that somatosensory-evoked potentials (SSEPs) may offer a solution. But can this relatively simple monitoring tool truly make a difference in preventing devastating neurological outcomes?

For surgical teams, the practical question isn't just 'does it work?' but 'can we realistically integrate this into our existing workflow?' This demands a hard look at the logistics, the potential for false positives, and the resources required to implement SSEP monitoring effectively during TCAR procedures.

Clinical Key Takeaways

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  • The PivotSSEP monitoring offers a potential real-time assessment of cerebral perfusion during TCAR TAVR, potentially allowing for immediate intervention to prevent ischemic injury.
  • The DataIn a case report, SSEP amplitude decreased significantly during balloon inflation, prompting adjustments that likely averted a stroke.
  • The ActionConsider incorporating SSEP monitoring into your TCAR TAVR protocol, ensuring that the anesthesiology and neurology teams are integrated into pre-operative planning and intraoperative monitoring.

The Clinical Challenge

Minimizing stroke risk remains paramount in TCAR TAVR. Despite advances in embolic protection devices and procedural techniques, the threat of neurological complications persists. The challenge lies in identifying cerebral hypoperfusion in real-time, allowing for immediate corrective action before irreversible damage occurs. Can we reliably detect these subtle changes, and can SSEPs provide a practical and actionable solution?

SSEPs: What the Guidelines Say

Current guidelines offer limited guidance on routine intraoperative neurophysiological monitoring for TAVR. The 2021 ACC/AHA/SCAI Guideline for the Management of Patients With Valvular Heart Disease mentions the importance of neurological assessment but does not specifically recommend SSEP monitoring. This is not a surprise, given the relative paucity of robust data supporting its routine use in this context. The European Society of Cardiology (ESC) guidelines are similarly silent on the issue. Therefore, any adoption of SSEP monitoring must be viewed as adjunctive, not standard of care, until more definitive evidence emerges.

The Case Report Details

The case report describes a patient undergoing TCAR TAVR where SSEP monitoring was employed. A significant decrease in SSEP amplitude was observed during balloon inflation, suggesting compromised cerebral perfusion. The surgical team responded by adjusting the balloon position and flow parameters, which led to a restoration of SSEP amplitude. Post-procedure neurological examination revealed no deficits, suggesting that the SSEP monitoring may have played a crucial role in preventing a stroke. While compelling, this is a single case. It does not establish causality but rather points toward a potential benefit warranting further investigation.

Limitations and Caveats

The most obvious limitation is the single-case nature of the report. We cannot extrapolate these findings to a broader population. Furthermore, SSEPs are susceptible to various confounding factors, including anesthesia depth, body temperature, and pre-existing neurological conditions. The sensitivity and specificity of SSEPs for detecting clinically significant cerebral hypoperfusion during TCAR TAVR remain undefined. It is entirely possible that a decrease in SSEP amplitude could trigger unnecessary interventions, leading to increased procedural time and potential complications. Before widespread adoption, we need prospective studies with clearly defined endpoints and rigorous statistical analysis to determine the true clinical utility of SSEP monitoring in this setting.

Integrating SSEPs into Your TCAR TAVR Program

If your heart team is considering incorporating SSEP monitoring, several practical considerations must be addressed. First, ensure that the anesthesiology team is experienced in SSEP monitoring and interpretation. The baseline SSEP should be established after induction and before any manipulation of the aortic valve. Clear communication protocols must be established between the surgical, anesthesiology, and neurology teams to ensure rapid response to any changes in SSEP amplitude. Finally, the cost of SSEP monitoring should be factored into the overall cost of the TCAR TAVR procedure. This includes the cost of the monitoring equipment, the neurologist's time for interpretation, and any additional resources required to manage potential complications arising from SSEP-guided interventions. A formal protocol, including decision trees based on SSEP changes, is essential to guide intraoperative management.

The integration of SSEP monitoring introduces logistical challenges. The need for specialized equipment and trained personnel adds to the procedural cost. Currently, there is no specific reimbursement code for SSEP monitoring during TCAR TAVR, which could create financial barriers for some hospitals. Furthermore, the potential for false positives could lead to increased procedural time and resource utilization. Clear protocols and standardized interpretation criteria are essential to minimize these risks.

LSF-0471937772 | January 2026


Ross MacReady
Ross MacReady
Pharma & Policy Editor
A veteran health policy reporter who spent 15 years covering Capitol Hill and the FDA. Ross specializes in the "business of science", tracking drug pricing, regulatory loopholes, and payer strategies. Known for his skepticism and deep sourcing within the pharmaceutical industry, he focuses on the financial realities that dictate patient access.
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How to cite this article

MacReady R. Sseps to monitor cerebral perfusion during tcar tavr procedures. The Life Science Feed. Published January 25, 2026. Updated January 25, 2026. Accessed January 31, 2026. .

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References
  • Otto, C. M., Nishimura, R. A., Bonow, R. O., Carabello, B. A., Erwin, J. P., Gentile, F., ... & Jacobs, J. P. (2021). 2020 ACC/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation, 143(5), e72-e227.
  • Vahanian, A., Beyersdorf, F., Praz, F., Milojevic, M., Baldus, S., Brochet, E., ... & Bueno, H. (2021). 2021 ESC/EACTS Guidelines for the management of valvular heart disease. European Heart Journal, 43(7), 561-632.
  • Katsumata, T., et al. "Usefulness of somatosensory-evoked potentials for monitoring cerebral perfusion during transcarotid transcatheter aortic valve replacement: a case report." Journal of Cardiothoracic Surgery (in press).
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