Cardiology

Endocarditis: Why fixed-dose ampicillin often misses the mark

A personalized antibiotic strategy, guided by therapeutic drug monitoring, optimizes ampicillin regimens in enterococcal bloodstream infections and endocarditis.

LAA occlusion: Less bleeding, but is stroke risk truly equal?

Left atrial appendage occlusion (LAAO) reduces nonprocedural bleeding in AF patients but shows no difference in stroke or mortality compared to medical therapy.

Eplontersen for ATTR-CM: Why a promising therapy fell short

Eplontersen, when added to standard care, did not demonstrate additional cardiovascular benefit for patients with ATTR-CM. The therapy's impact on cardiac outcomes remains unconfirmed.

DOACs for AFib: Are intermediate-risk patients getting the protection they need?

Direct oral anticoagulants (DOACs) reduce clinical events in atrial fibrillation patients at intermediate stroke risk, challenging prior assumptions about optimal management in this group.

Milvexian fails to cut ischemic risk in recent ACS, raising questions for FXIa inhibitors

Milvexian did not reduce ischemic events in patients with recent acute coronary syndrome, despite its mechanism as a factor XIa inhibitor.

Biomarkers predict early rhythm control benefit in AFib

Early rhythm control's benefit in atrial fibrillation varies by baseline biomarker levels, with higher NT-proBNP and hs-cTnT indicating greater risk reduction.

Navigating Dilated Cardiomyopathy: Beyond Standard Care

Dilated cardiomyopathy management focuses on symptom control, preventing disease progression, and reducing adverse cardiac events through guideline-directed medical therapy.

Atorvastatin's CV Benefit in Older Adults: More Nonfatal Events Than Deaths?

Atorvastatin reduces major cardiovascular events in older adults, with the benefit primarily driven by a reduction in nonfatal events rather than mortality.

Statins: When to start primary prevention after age 70?

Statins can reduce the risk of first heart attack and stroke by approximately 30% in individuals over 70 years of age.