All articles200
Combination Oncology Therapies: A Review of Efficacy and Access
Combination oncology therapies offer improved outcomes for cancer patients but present significant challenges in access and cost.
Diagnostic Inconsistencies Challenge STEMI Paradigm's Simplicity
The STEMI paradigm's reliance on fixed ST-elevation criteria for acute coronary occlusion is questioned due to diagnostic inconsistencies.
Ultra-Processed Foods Linked to 32 Adverse Health Outcomes
An umbrella review of epidemiological meta-analyses establishes a direct association between ultra-processed food consumption and 32 adverse health outcomes.
Public Health Measures Significantly Reduced COVID-19 Incidence
A systematic review and meta-analysis confirmed the effectiveness of public health measures in reducing COVID-19 incidence, transmission, and mortality.
Data Integrity Concerns Raised in Pfizer's COVID-19 Vaccine Trial
A former regional director for Ventavia Research Group has raised concerns regarding data integrity and regulatory oversight in Pfizer's COVID-19 vaccine trial.
30 US Doctors Declare Trump Mentally Unfit, Citing Public Behaviour
Thirty senior US doctors have declared former President Trump mentally unfit for office, based on observations of his public behaviour.
Calcium, Vitamin D Supplementation Lacks Fracture or Fall Prevention Efficacy
A systematic review and meta-analysis found no evidence that calcium, vitamin D, or combined supplementation prevents fractures or falls.
Key Witness in Lucy Letby Trial Under Employer Investigation
A key medical witness in the Lucy Letby trial was under investigation by his employers, a detail relevant to trial proceedings.
PRISMA 2020: Updated Guideline for Systematic Reviews
The PRISMA 2020 statement provides an updated framework for reporting systematic reviews, enhancing transparency and completeness.
Airway Management: Protocols Under Review for OHCA and ILD
New protocols are examining ventilation strategies for out-of-hospital cardiac arrest and interstitial lung disease, with current best practices unclear.
Addressing Idea Misappropriation in Professional Settings
This article examines strategies for managing professional idea theft, focusing on documentation and communication to protect intellectual contributions.
Compassion in Dementia Diagnosis: Patient Perspectives Highlighted
A BMJ perspective piece underscores the critical role of compassion in the dementia diagnostic journey, advocating for patient-centered communication.
AI's Dual Impact on UK Mental Health: Risks and Opportunities
AI presents both potential benefits and significant risks to UK mental health, requiring careful implementation and regulatory oversight.
Metabolic Dysfunction Associated Steatotic Liver Disease: An Overview
A recent review outlines the mechanisms, diagnosis, and management of metabolic dysfunction associated steatotic liver disease (MASLD) in adults.
Vaccine Cold Chain Integrity Underpins Vaccine Security
Maintaining vaccine cold chain integrity is essential for vaccine security, as highlighted by recent research on vaccine preventable diseases.
Recurrent Concussion Linked to Reduced CBF in Female Athletes
Female collegiate athletes with recurrent concussions show reduced cerebral blood flow, particularly in frontotemporal regions, a sex-specific association.
Current and Emerging Therapies for Pulmonary Tuberculosis
A recent review outlines current and emerging therapies for pulmonary tuberculosis in adults, addressing treatment challenges.
GLP-1RAs: No Increased Risk of Acute Pancreatitis vs. Sulfonylureas
A target trial emulation found no increased risk of all-cause or cause-specific acute pancreatitis with GLP-1RA initiation versus sulfonylureas.
Bisphosphonate Interruption Reduces Fragility Fracture Risk
A nested case-control and cohort study in England found that interrupting bisphosphonate therapy after 3 or 5 years reduced fragility fracture risk.
DRC Ebola Outbreak Exposes Global Health Underfunding Consequences
The 2026 BMJ study highlights how the Democratic Republic of Congo's Ebola outbreak revealed critical deficiencies in global health funding.
Ebola Outbreak May Become Deadliest on Record, Agencies Warn
Aid agencies caution that the current Ebola outbreak has the potential to become the deadliest recorded, according to a recent report.
Ebola: Essential Information for Suspected Cases
Ebola virus disease (EVD) presents a significant public health concern. Rapid identification and isolation are critical for containment.
Three Vaccines in Development for Bundibugyo Ebola Outbreak
Three investigational vaccines are being fast-tracked for development following an Ebola Bundibugyo outbreak, addressing a critical unmet need.
Patient-Reported Factors Redefine Alopecia Areata Severity
New research characterizes patient-reported factors beyond scalp hair loss that contribute to alopecia areata severity.
Nausea, Jaundice in Burn Patients: Early Cholestasis Recognition Critical
Nausea and jaundice in burn patients may indicate cholestasis, a serious complication requiring prompt diagnosis and management to prevent further morbidity.
PGP: Factors for Return to Meaningful Activities Postpartum
New research identifies factors associated with long-term functional outcomes for women experiencing pregnancy-related pelvic girdle pain (PGP).
PMOS: Clinical Implications for Patient Management
Understanding the impact of PMOS on patient quality of life is essential for GPs and specialists to guide appropriate management strategies.
Preterm Birth Linked to Long-Term Cognitive Deficits
Preterm birth is associated with persistent cognitive deficits across childhood and adolescence, impacting academic performance and daily function.
Fluconazole and Osilodrostat Linked to Adrenal Crisis in EAS
A case report describes adrenal crisis in a patient with ectopic ACTH syndrome receiving fluconazole and osilodrostat for cryptococcal infection.
Scalp Lesions: Rare Malignancies Mimic Benign Conditions
Ulcerated scalp lesions, often misdiagnosed as benign, can represent rare malignancies such as sebaceous carcinoma or leukemia cutis.
AI-Assisted Fetal Echocardiography Improves Early CHD Detection
Artificial intelligence (AI) integration into fetal echocardiography improves early detection of congenital heart disease (CHD), including aortic stenosis.
Down Syndrome: Skin Conditions Demand Dermatologists’ Attention
Individuals with Down syndrome frequently present with specific dermatological conditions that necessitate targeted clinical management and specialist referral.
Risankizumab Shows Efficacy in Refractory Crohn's Real-World Data
Real-world data indicate risankizumab is effective in highly refractory Crohn's disease, including patients with prior advanced therapy exposure.
Timely 'Nudges' Improve Patient Care Goal Discussions
Implementing timely prompts for clinicians can significantly increase discussions about patient care goals, enhancing patient-centered care.
Multivalent Meningococcal Conjugate Vaccines Modelled for African Belt
A new model evaluates multivalent meningococcal conjugate vaccines (MMCVs) in the African meningitis belt, assessing optimal vaccination strategies.
Breastfeeding in High-Demand Specialties: A Feasibility Review
Female doctors in high-demand specialties face significant challenges in maintaining breastfeeding, impacting both maternal and infant health outcomes.
Physicians Must Uphold 'Do No Harm' with Compounded Medications
Compounded medications, while necessary for specific patient needs, carry inherent risks that necessitate strict adherence to 'do no harm' principles by prescribing physicians.
AI System Achieves Over 90% Accuracy in Colonoscopy Surveillance
An AI system accurately selected appropriate colonoscopy surveillance intervals in over 90% of cases, potentially streamlining post-polypectomy care.
Diabetes Increases Post-Transplant Mortality Risk
Diabetes, including post-transplant diabetes mellitus (PTDM), is linked to increased cardiovascular events, graft dysfunction, and mortality after organ transplantation.
Cryoprobe Biopsy Improves Diagnostic Yield in Transbronchial Biopsy
Cryoprobe transbronchial biopsy offers a higher diagnostic yield and improved specimen quality compared to conventional forceps biopsy.
Daraxonrasib Extends Overall Survival in Pancreatic Cancer
New data on daraxonrasib demonstrate a significant extension in overall survival for patients with advanced pancreatic cancer, addressing a critical unmet need.
Fast Five Quiz: Bladder Cancer Presentation and Diagnosis
This quiz addresses common clinical scenarios in bladder cancer, focusing on initial presentation, diagnostic pathways, and key risk factors.
Air Embolism: Two Cases After Percutaneous Lung Biopsy
Two cases highlight the rare but severe complication of air embolism following percutaneous lung biopsy, necessitating prompt recognition and management.
Fast Five Quiz: Assessment of Tardive Dyskinesia
This quiz addresses key aspects of tardive dyskinesia (TD) assessment, focusing on diagnostic criteria, screening, and differential diagnosis.
Lyme Neuroborreliosis in Older Man After Tick Bite: A Case Review
A case review details Lyme neuroborreliosis in an older male following a tick bite, highlighting diagnostic challenges and treatment responses.
GLP-1 Agonists Prompt Aesthetic Concerns, Nonsurgical Trends
GLP-1 agonist-associated weight loss is driving patient aesthetic concerns and increasing demand for nonsurgical treatments.
Big Pharma Employs UK Drug Pricing Tactics Across Europe
Pharmaceutical companies are replicating UK-style market access strategies to influence drug pricing negotiations in other European countries, impacting national healthcare budgets.
AI in Gastroenterology: Benefits, Risks, and Safeguards for Practice
Artificial intelligence (AI) offers potential for enhanced diagnostic accuracy and efficiency in gastroenterology, but requires careful implementation.
Sexual Assault Nurse Examiners: Essential Role in Forensic Care
Sexual Assault Nurse Examiners (SANEs) provide critical, specialised care for survivors of sexual assault, integrating medical treatment with forensic evidence collection.
Low-Dose Steroids Don't Impair ICI Survival
Concurrent low-dose corticosteroid use does not negatively impact overall survival in patients receiving immune checkpoint inhibitors.
Peptide-Based Preparations May Invert Colonoscopy Risk Profile
Novel peptide-based preparations for colonoscopy may mitigate the risks associated with inadequate bowel cleansing, potentially inverting the traditional risk-benefit profile.
Tailoring Prostate Cancer Care in Men With Limited Longevity
Prostate cancer management in men with limited life expectancy requires careful consideration to balance treatment benefits against potential harms.
GLP-1 Receptor Agonists and Psoriatic Disease: A Deep Dive
GLP-1 receptor agonists, primarily for type 2 diabetes and obesity, show emerging evidence for modifying psoriatic disease activity.
Orforglipron Oral GLP-1 Shows Efficacy in Phase 3 T2D Trials
Oral GLP-1 receptor agonist orforglipron demonstrated significant reductions in HbA1c and body weight in Phase 3 trials for type 2 diabetes.
Clopidogrel and Omeprazole: Re-evaluating Concomitant Use Risk
Concomitant use of clopidogrel and omeprazole has been a clinical concern due to potential drug-drug interactions impacting clopidogrel efficacy.
Glucosamine/Chondroitin Tied to Faster AD Progression
A recent analysis indicates that regular use of glucosamine and chondroitin may accelerate Alzheimer's disease progression in susceptible individuals.
Medical Residency Competitiveness Rises Amidst Applicant Surge
The landscape for medical residency applications is increasingly competitive, driven by a growing applicant pool and static residency positions.
Ozempic Mouth: Understanding Xerostomia and Oral Health Risks
Semaglutide's impact on salivary flow can lead to xerostomia, increasing risks of dental caries and periodontal disease. Management focuses on symptomatic relief and preventive oral care.
HPV Vaccine at 20: Progress and Persistent Challenges
The HPV vaccine has significantly reduced cervical cancer incidence over 20 years, yet global coverage disparities persist.
Goat Milk Formula Linked With Less Atopic Dermatitis
Infants fed goat milk formula demonstrated a reduced incidence of atopic dermatitis compared to those on cow milk formula, according to recent observations.
Multiple Clinical Factors Tied to Poor Bipolar Med Adherence
Poor adherence to bipolar disorder medication is influenced by several clinical factors, including psychiatric comorbidities and substance use.
High-Dose Omega-3 Fails to Improve Cognition in Older Adults
A large-scale trial found no cognitive benefit from high-dose omega-3 fatty acid supplementation in older adults with normal cognition.
Chemoradiation Improves Survival in Unresected Pancreatic Cancer
A retrospective analysis indicates chemoradiation combined with systemic therapy improves survival in unresected pancreatic cancer.
Real-World Data Confirm Risankizumab Efficacy in Crohn's Disease
New real-world data from the ENEIDA registry and other analyses confirm risankizumab's effectiveness in refractory Crohn's disease, including endoscopic outcomes.
MRI Predicts Rectal Cancer Survival Better Than Pathology
New research indicates MRI-based features and AI models may offer superior prognostic value in rectal cancer compared to traditional pathology.
Monoclonal Antibodies May Complicate Transfusion Testing
Monoclonal antibodies, particularly IgG4 anti-CD47, may induce erythrophagocytosis and interfere with transfusion compatibility testing, posing a challenge for patient management.
WHO Urges Preparedness for 'Disease X' Pandemic Threat
The WHO has issued a warning regarding 'Disease X', an unknown pathogen with pandemic potential, necessitating urgent global preparedness.
Single Question May Flag Poor Quality Sleep in Patients
A simple, single-item screening question may effectively identify patients experiencing poor quality sleep, facilitating earlier intervention.
Protein and Creatine Supplement Use Expands Beyond Niche Demographics
Once confined to athletes, protein and creatine supplements are now widely used across diverse populations, necessitating clinician awareness.
Ocular Allergy Treatment May Require Multi-Specialty Collaboration
Effective management of ocular allergy, particularly severe or refractory cases, often necessitates collaboration between ophthalmologists and allergy/asthma specialists.
Trump Order Seeks Child Vaccine Schedule Change
A recent executive order aims to alter the recommended childhood vaccine schedule, prompting discussion on public health implications and established medical guidelines.
Pharmacy Benefit Manager Reforms Address Systemic Issues
New legislative and regulatory reforms aim to rectify the 'fundamentally broken' pharmacy benefit manager (PBM) system, targeting opaque pricing and rebate practices.
US Reengagement with Gavi Alliance Aims to Bolster Ebola Vaccine Access
The US intends to reengage with Gavi, the Vaccine Alliance, to enhance global access to Ebola vaccines amidst ongoing outbreaks, signaling a shift in international health policy.
Medical School Funding Changes: New July Rule Alters Student Payments
A new rule effective July will significantly change how medical students finance their education, impacting loan structures and repayment obligations.
AMA Calls for AI Regulation in Clinics, Insurance to Protect Judgment
The American Medical Association advocates for AI regulation in clinical and insurance settings, emphasising that AI must augment, not replace, physician judgment.
AI Scribes: Physician Perceptions Range from 'Friend' to 'Threat'
Physician views on AI scribes vary widely, from seeing them as beneficial tools to concerns about their impact on clinical practice.
AI System Achieves >90% Accuracy in Colonoscopy Surveillance
An AI system demonstrated over 90% accuracy in selecting appropriate colonoscopy surveillance intervals, potentially reducing unnecessary procedures.
Weekly survodutide reduces obesity and metabolic liver disease
Weekly survodutide demonstrates dual efficacy in reducing body weight and improving markers of metabolic dysfunction-associated steatotic liver disease (MASLD).
Oncologist Reflects on Football's Lessons for Clinical Practice
A clinical oncologist discusses how principles from football, such as teamwork and strategic planning, inform their approach to patient care.
Andes Orthohantavirus Outbreak Linked to Cruise Ship Travel
An Andes orthohantavirus outbreak, involving 13 cases with a 23% case-fatality rate, has been linked to an expedition cruise ship.
GLP-1s do not improve migraines, but reduce healthcare utilisation
GLP-1 receptor agonists do not reduce migraine days, but are associated with decreased healthcare utilisation for migraine.
HHS Proposes Loosening Testosterone Therapy Warning Requirements
The HHS has proposed changes to testosterone therapy warnings, potentially reducing emphasis on cardiovascular risk. This may alter prescribing practices for hypogonadism.
Aggressive Ocular Management Essential for Cancer Drug Complications
Proactive and often aggressive management of ocular toxicities from cancer therapies is critical to preserve vision and maintain treatment adherence.
AI to Become Colleague for Infection Preventionists
Artificial intelligence is poised to integrate into infection prevention, offering support in surveillance, outbreak detection, and resource allocation.
Hypotension Linked to Increased Alzheimer's Disease Risk
New research indicates that mid-life hypotension is a significant cardiovascular risk factor for later-life Alzheimer's disease, challenging prior assumptions.
Pembrolizumab Reduces Pulmonary AEs vs Chemotherapy in NSCLC
Pembrolizumab monotherapy demonstrated a lower incidence of pulmonary adverse events compared to platinum-based chemotherapy in advanced NSCLC.
Congo Ebola Response Strained One Month Post-Emergency Declaration
The Ebola response in the Democratic Republic of Congo faces significant operational challenges one month after the WHO declared an international emergency.
Paroxetine's Mechanism in Rosacea: Serotonin Pathway Clues
Paroxetine, a selective serotonin reuptake inhibitor, may modulate neurovascular dysregulation in rosacea via serotonin pathway interactions.
Remibrutinib Resolves Chronic Inducible Urticaria Symptoms
A novel BTK inhibitor, remibrutinib, demonstrated efficacy in resolving symptoms of chronic inducible urticaria in clinical trials.
Cannabis Psychosis Presents With Distinct Symptom Pattern
First-episode psychosis associated with cannabis exposure shows a distinct symptom profile compared to non-cannabis-associated psychosis.
Dupilumab Superior to Omalizumab in High-Biomarker Asthma
Dupilumab demonstrated superior efficacy compared to omalizumab in patients with high-biomarker severe asthma, particularly regarding exacerbation rates and lung function.
BMA Challenges GMC Appeal Powers in High Court
The BMA has initiated legal action against the GMC regarding its power to appeal fitness to practise decisions, citing concerns over fairness.
Lifestyle Interventions Outperform Metformin for Healthy Aging
Evidence suggests comprehensive lifestyle modifications offer superior benefits for healthy aging compared to metformin monotherapy.
Poor Midlife Sleep Linked to Worse Well-Being Years Later
Insufficient sleep duration in midlife is associated with a decline in well-being and increased depressive symptoms in later life.
Blood Transfusion Safety: Pathogen Inactivation Reduces Transfusion-Transmitted Infections
Modern blood transfusion practices, including pathogen inactivation, have significantly reduced the risk of transfusion-transmitted infections, improving patient safety.
Biosimilars: A Sustainable Strategy for Healthcare Systems
Biosimilars are a critical strategy for improving access to high-cost biologics and ensuring healthcare system sustainability worldwide.
Heat-Attributable CVD Years of Life Lost Projected to Rise Through 2050
Projections indicate a substantial increase in years of life lost due to cardiovascular disease attributable to heat exposure by 2050.
Ocular Allergy Rates Rise, Prompting Collaborative Eco-Conscious Interventions
Rising ocular allergy prevalence necessitates integrated clinical and environmental strategies to mitigate disease burden and improve patient outcomes.
Treatment Intensification Underutilized in Metastatic Prostate Cancer
Real-world data indicates treatment intensification is underutilized in metastatic prostate cancer, impacting first-line mCRPC outcomes.
AI Model Identifies Prostate Cancer Patients for Genetic Testing
An AI model accurately identifies men with prostate cancer who are eligible for germline genetic testing, improving adherence to guideline recommendations.
ADT Break May Benefit Responders in Metastatic Prostate Cancer
Intermittent androgen deprivation therapy (ADT) may offer a quality of life advantage for responders in metastatic prostate cancer.
Radiopharmaceuticals Show Promise in Metastatic Prostate Cancer
New data support further investigation of radiopharmaceuticals, including anti-SSTR and 177Lu-PSMA-617, for metastatic prostate cancer.
Breast Cancer in Transgender Individuals: More Research Needed
Current literature on breast cancer in transgender and gender-diverse individuals is limited, highlighting a need for more inclusive research and care strategies.
GLP-1 Agonists: Less Weight Loss, Possible Breast Cancer Survival
GLP-1 receptor agonists, while not primarily indicated for oncology, show potential for survival benefits in breast cancer patients.
Metastatic ILC Survival Varies by Mutational Signature
Survival outcomes in metastatic invasive lobular carcinoma (ILC) differ based on specific mutational signatures, impacting treatment stratification.
T-DXd Side Effects in Breast Cancer Warrant Continued Attention
Clinicians must maintain vigilance for adverse events associated with trastuzumab deruxtecan (T-DXd) in breast cancer, particularly interstitial lung disease.
ADA Leader Apologizes for Meeting Removals, Broader Community Concerns
The American Diabetes Association's CEO issued an apology following the removal of members from a meeting, addressing broader community concerns.
Pesticide Exposure Linked to Early-Onset Colorectal Cancer Risk
A common pesticide, permethrin, has been associated with an increased risk of early-onset colorectal cancer, prompting questions about environmental factors in disease etiology.
ACP Issues Guidance on Medications for Obesity, Overweight
The American College of Physicians (ACP) has released new guidance on pharmacologic treatments for obesity and overweight, focusing on efficacy and safety.
Backdoor Roth IRA: A Strategic Necessity for High-Earning Surgeons
High-earning surgeons face income limitations for direct Roth IRA contributions. The backdoor Roth IRA offers a compliant method to access tax-free growth and withdrawals in retirement.
FDA Approves Skinvive for Facial Wrinkles, Including 'Tech Neck' Lines
The FDA has approved Skinvive, an injectable hyaluronic acid gel, for improving skin smoothness and reducing facial wrinkles, including those on the neck.
Metronidazole Reduces Hysterectomy SSIs in Hospital Audit
A hospital audit revealed a significant reduction in surgical site infections (SSIs) following hysterectomy after implementing metronidazole prophylaxis.
Bayer Acquires Perfuse Therapeutics for Ocular Disease Pipeline
Bayer has acquired Perfuse Therapeutics, expanding its ophthalmology pipeline with a focus on diabetic retinopathy and other ocular conditions.
UNAIDS Warns Funding Cuts Threaten HIV/AIDS Progress
UNAIDS reports that reduced funding for HIV/AIDS programmes risks reversing previous gains, potentially increasing new infections and mortality.
ESC Cardio-Oncology 2026: Key Sessions and Anticipated Focus Areas
The ESC Cardio-Oncology 2026 congress will address cardiotoxicity from cancer therapies, focusing on early detection and management strategies.
ADA 2026: Key Diabetes Trials to Watch
The upcoming ADA 2026 conference will feature pivotal trials in diabetes management, focusing on novel GLP-1 receptor agonists and SGLT2 inhibitors.
Disability Insurance: Essential Considerations for Medical Residents
Medical residents face unique challenges in securing disability insurance. Understanding policy types and key features is critical for financial protection.
CMS Adopts Performance-Based Standards for CRC Biomarker Tests
The Centers for Medicare & Medicaid Services (CMS) has implemented new performance-based standards for colorectal cancer (CRC) biomarker tests, despite ongoing questions regarding the clinical utility of some assays.
Professional Growth Through Purposeful Imbalance
Achieving professional growth in demanding medical fields may necessitate periods of 'purposeful imbalance' rather than strict work-life equilibrium.
FDA Clears OTC CGM for Non-Insulin-Using Children Aged 2+
The FDA has cleared an over-the-counter continuous glucose monitor for children aged 2 years and older who do not use insulin.
Purposeful Imbalance: A Strategy for Professional Growth
Achieving professional growth may necessitate a strategic, temporary deviation from conventional work-life balance, termed 'purposeful imbalance.'
Exercise Declined in Patients with Obesity After Starting a GLP-1
Patients with obesity showed reduced physical activity after initiating GLP-1 receptor agonists, according to a recent analysis.
GLP-1 Receptor Agonists Linked to Elevated Hypotension Risk
GLP-1 receptor agonists are associated with an increased incidence of hypotensive events, particularly in patients with pre-existing cardiovascular risk factors.
Classic CAH: New Approaches to Glucocorticoid Dosing
Endocrinology specialists are re-evaluating glucocorticoid dosing strategies for classic congenital adrenal hyperplasia (CAH), focusing on individualised regimens to balance androgen control and minimise adverse effects.
Low Alkaline Phosphatase: Recognizing Clinical Consequences
Low alkaline phosphatase (ALP) is often overlooked, but its clinical consequences, particularly hypophosphatasia, warrant increased diagnostic vigilance.
Afirma Molecular Testing: Unique Situations and New Prognostic Development
Afirma molecular testing aids thyroid nodule management, particularly in indeterminate cytology. New prognostic markers enhance risk stratification.
Severe Hypoglycemia in T1D: Enhancing Patient-Clinician Dialogue
Addressing severe hypoglycemic events in type 1 diabetes requires direct, empathetic clinician-patient conversations to improve management and outcomes.
Endocrinologists' Role in Early Thyroid Eye Disease Recognition
Early recognition of thyroid eye disease (TED) by endocrinologists is critical for optimal patient outcomes, enabling timely intervention.
XLH Adults: Osteomalacia Persists Despite Conventional Therapy
Adults with X-linked hypophosphatemia (XLH) frequently experience persistent osteomalacia, even with conventional phosphate and active vitamin D treatment.
GLP-1 RAs Reduce CV Risk in T2D Via Weight, Glucose Pathways
GLP-1 receptor agonists offer cardiovascular risk reduction in type 2 diabetes through both weight loss and direct glucose-lowering mechanisms.
Desmopressin Dosing Refined for Central Diabetes Insipidus
New insights into desmopressin administration for central diabetes insipidus (CDI) aim to optimise efficacy and minimise hyponatremia risk.
Defining Hyperphagia Treatment Possibilities in Prader-Willi Syndrome
Clinician and caregiver perspectives highlight the complex challenges and unmet needs in managing hyperphagia in Prader-Willi Syndrome.
Hypoparathyroidism Treatment: Patient, Care Partner, HCP Perspectives
New perspectives on hypoparathyroidism treatment from patients, care partners, and HCPs highlight unmet needs and treatment goals.
Liver-Directed Treatment Shows Efficacy in Metabolic Dysfunction
A novel liver-directed treatment presented at endo 2026 offers a targeted approach for metabolic dysfunction, addressing a significant unmet clinical need.
GLP-1 Agonists and Ischemic Optic Neuropathy: A Review
GLP-1 receptor agonists are widely used for type 2 diabetes and weight management. Recent data suggests a potential association with ischemic optic neuropathy.
FDA Approves First New Sunscreen Active Ingredient in Two Decades
The FDA has approved a new sunscreen active ingredient, bemotrizinol, marking the first such approval in over 20 years. This offers a new option for broad-spectrum UV protection.
GLP-1 Weight Regain: Emerging Strategies to Sustain Loss
Strategies are emerging to mitigate weight regain post-GLP-1 receptor agonist discontinuation, focusing on sustained pharmacological intervention.
Doctors' Regrets: Understanding Their Evolution and Management
Physician regret is a common, evolving experience impacting well-being and practice. Understanding its trajectory is key to mitigation.
Retatrutide Shows 24.2% Weight Reduction in Phase II Trial
A Phase II trial of retatrutide demonstrated substantial weight loss and improvements in cardiometabolic markers in adults with obesity.
Oxygen Titration Protocol Reduces Severe Hyperoxemia in ED
A structured oxygen titration protocol in the emergency department significantly reduced the incidence of severe hyperoxemia, improving patient outcomes.
Racial Bias in Clinical Algorithms Increases Health Disparities
Racial bias embedded in clinical algorithms leads to suboptimal care and increased morbidity for minority patients, necessitating urgent re-evaluation.
Psoriasis Workup Expands Beyond Skin: SDPA 2026 Highlights Systemic Risk
Psoriasis management is evolving, with new guidance emphasizing systemic comorbidities beyond dermatological manifestations.
Belzutifan Plus Pembrolizumab Approved for Adjuvant RCC
The FDA has approved belzutifan plus pembrolizumab for adjuvant renal cell carcinoma, offering a new option for patients at high risk of recurrence.
Virtual Team-Based GI Care Superior to Traditional Care
A virtual team-based care model for gastrointestinal conditions demonstrated superior patient outcomes and reduced healthcare utilisation compared to traditional care.
Chemo-Free Therapy Improves Outcomes in Pediatric APL (EHA 2026)
Chemotherapy-free regimens for pediatric acute promyelocytic leukemia (APL) demonstrate superior efficacy and reduced toxicity compared to traditional chemotherapy.
Medical Residency Competitiveness Rises, Posing Workforce Challenges
The number of medical school graduates seeking residency positions continues to outpace available slots, intensifying competition and impacting physician workforce distribution.
OTC CGM Approved for Paediatric Diabetes Management
Over-the-counter continuous glucose monitoring (CGM) systems are now approved for use in children aged two years and older.
Cellular Reprogramming: Reversing Age-Related Phenotypes in Vitro
Research into cellular reprogramming aims to reverse age-related cellular phenotypes, with early studies demonstrating partial reversal in vitro.
Oral GLP-1 Analogues Show A1c Reduction, Weight Loss at ADA 2026
New data presented at ADA 2026 indicates novel oral GLP-1 receptor agonists significantly lower HbA1c and body weight in type 2 diabetes.
GLP-1 Receptor Agonists: Understanding Oral Manifestations
GLP-1 receptor agonists, used for type 2 diabetes and weight management, are associated with xerostomia and other oral health issues.
GBD 2023: Lower Respiratory Infections Remain Leading Infectious Cause of Death
The Global Burden of Disease Study 2023 confirms lower respiratory infections as the world's leading infectious cause of death.
Radiotherapy and the Heart: Damage, Protection, or Treatment?
Radiotherapy, a cancer treatment, can damage the heart. New research explores hydrogels for protection and the impact of adjuvant therapies.
Cardiovascular Disease and Cancer: A Reciprocal Relationship
Cardiovascular disease and cancer share common risk factors and exhibit a reciprocal relationship, impacting patient outcomes and treatment strategies.
GBD 2023: LRIs Remain Leading Infectious Cause of Death Globally
The Global Burden of Disease Study 2023 confirms lower respiratory infections (LRIs) as the leading infectious cause of death worldwide.
Comprehensive Care Improves Outcomes for CAYA Cancer Survivors
Comprehensive, multidisciplinary care models are essential for childhood, adolescent, and young adult (CAYA) cancer survivors to mitigate long-term sequelae.
Cardio-Oncology Guidelines: Standardizing CTRCD Management
A consensus statement provides practical guidance for hematology and oncology providers on managing cancer therapy-related cardiac dysfunction (CTRCD).
Cardio-Oncology: Addressing Unmet Needs at ESC Cardio Oncology 2026
Cardio-oncology faces significant unmet needs in patient management, necessitating integrated care pathways and novel therapeutic strategies.
GBD 2023: Cancer and Cardiovascular Disease Mortality Trends Examined
The Global Burden of Disease Study 2023 provides updated cause-specific mortality estimates, offering insights into global health trends.
Cardiotoxicity Monitoring: Evidence-Based Shift from Traditional Methods
ESC Cardio-Oncology 2026 discussions highlight the need to move from traditional cardiotoxicity monitoring to evidence-based strategies.
Cardio-Oncology 2026: Phenotypes, Mechanisms, and Cardioprotection
ESC Cardio Oncology 2026 addressed heart failure and cancer therapy-related cardiac dysfunction, focusing on phenotypes, mechanisms, and cardioprotection.
Cardiovascular Disease and Cancer: A Reciprocal Relationship
Cardiovascular disease and cancer share common risk factors and treatment toxicities, necessitating integrated patient management.
ESC Cardio-Oncology 2026: Bridging Oncology and Cardiology
The 2026 ESC Cardio-Oncology meeting will focus on integrating oncology and cardiology to manage cardiovascular toxicities.
CTRCD Incidence Varies by Cancer Therapy in KP CHEMO Study
New data from the KP CHEMO study quantifies the real-world incidence of cancer therapy-related cardiac dysfunction (CTRCD) across diverse cohorts.
ICI-Related Cardiac Injury: Myocarditis, Coronary, Conduction Disease
Immune checkpoint inhibitors (ICIs) are associated with diverse cardiac toxicities, including myocarditis, coronary artery disease, and conduction abnormalities.
AI-Enabled Cardiocare Pathway Improves Cardio-Oncology Across Ages
An AI-enabled cardio-oncology pathway, Cardiocare, demonstrated improved patient management across age groups at ESC Cardio-Oncology 2026.
Cardio-Oncology 2026: Multidisciplinary Care Expands for Cancer Patients
The 2026 ESC Cardio-Oncology meeting highlights the evolving need for integrated care to manage cardiovascular toxicities in cancer patients.
ESC Cardio-Oncology 2026: Heart Failure Phenotyping in Cancer
ESC Cardio-Oncology 2026 addressed heart failure phenotyping in cancer patients, focusing on imaging and clinical decisions.
ADT and Cardiovascular Risk in Prostate Cancer: ESC Cardio-Oncology 2026
Androgen deprivation therapy (ADT) for prostate cancer increases cardiovascular risk. Clinicians must balance oncological benefit with cardiac safety.
Recognising and Monitoring Cardiac AL Amyloidosis: ESC 2026 Update
Early recognition and consistent monitoring of cardiac involvement in AL amyloidosis are critical for patient prognosis. This update outlines key diagnostic and management strategies.
Fluoropyrimidine Cardiotoxicity: Management Strategies at ESC Cardio Oncology 2026
ESC Cardio Oncology 2026 addressed fluoropyrimidine cardiotoxicity, outlining clinical challenges and emerging management strategies for this common chemotherapy complication.
Obesity Care: Tailored Treatment Strategies Highlighted at endo 2026
Personalised treatment approaches for obesity, moving beyond a 'one-size-fits-all' model, were a key focus at endo 2026.
Hypercortisolism: Emerging Diagnostic and Management Insights
New evidence presented at Endo 2026 refines our understanding of hypercortisolism, impacting diagnostic strategies and therapeutic approaches.
12 Months of Romosozumab Builds Bone Density in Postmenopausal Osteoporosis
A 12-month course of romosozumab significantly increases bone mineral density in postmenopausal women with osteoporosis.
Cushing's Syndrome: Addressing Diagnostic Delays and Treatment Gaps
Cushing's syndrome presents a diagnostic challenge, often leading to significant delays in treatment initiation and suboptimal patient outcomes.
Desiccated Thyroid Extract: Efficacy and Safety in Hypothyroidism
A case-based discussion at endo 2026 reviewed the role of desiccated thyroid extract (DTE) in hypothyroidism management, highlighting patient selection and comparative efficacy.
Korlym® Improves Cushing's Syndrome Symptoms in Patient Experience Data
New data from endo 2026 highlights patient-reported improvements in Cushing's syndrome symptoms with Korlym® (mifepristone) treatment.
Peer Insights on Once-Daily Weight Management Therapy at endo 2026
Endocrinology specialists discussed the clinical utility of a once-daily treatment for weight management in appropriate adult patients.
Hypothyroidism: Symptom Burden Persists Despite Euthyroidism
Many patients with hypothyroidism report persistent symptoms despite achieving biochemical euthyroidism, highlighting a significant symptom-treatment gap.
Endo 2026: Risk-Based Osteoporosis Management Refines Clinical Practice
Endo 2026 highlighted refined risk-based strategies for osteoporosis care, advocating for tailored interventions beyond universal guidelines to improve patient outcomes.
Steroidogenesis Inhibitor Targets Root Cause of Cushing’s Syndrome
A novel steroidogenesis inhibitor presented at ENDO 2026 offers a targeted approach to endogenous Cushing's syndrome by reducing cortisol overproduction.
Acromegaly Management: Focus on Biochemical Control at ENDO 2026
New insights from ENDO 2026 highlight the persistent challenges in achieving biochemical control for acromegaly patients.
Personalized Hemophilia Care: EHA 2026 Highlights Individualized Approaches
EHA 2026 discussions focused on individualized hemophilia care, moving beyond standard prophylaxis to tailored treatment strategies based on patient-specific factors.
Macrophages: Dual Role in Haematological Malignancies Explored
Macrophages exhibit a dual role in haematological malignancies, acting as both tumour suppressors and promoters, influencing disease progression and therapeutic responses.
Molecular Hematology: From Gene Profiles to Therapy Profiles at EHA 2026
EHA 2026 will review a quarter-century of molecular hematology, focusing on the integration of genomic data into targeted therapeutic strategies.
Housing Instability Linked to Persistent Diabetic Retinopathy Disparities
A study found that housing instability contributes to persistent disparities in diabetic retinopathy outcomes, even among treatment-adherent individuals.
Brief Brain Stimulation Effective for Depression in Parkinson's Disease
Magnetic seizure therapy (MST) demonstrated non-inferiority to ultra-brief electroconvulsive therapy (ECT) for depression, with fewer cognitive adverse effects.
PMOS: Insulin Resistance Impacts Fertility and Pregnancy Outcomes
Insulin resistance is a key factor in Polycystic Ovary Syndrome (PMOS), affecting reproductive health and increasing pregnancy complications.
Home-Based Stimulation for Bipolar Depression Shows Mixed Efficacy
Home-based transcranial direct current stimulation (tDCS) for bipolar depression yields inconsistent results, with some studies showing modest benefits while others report no significant difference from sham.
AD Biomarkers Linked to Worse Cognition in Midlife Adults
Elevated Alzheimer's disease biomarkers in midlife adults are associated with poorer cognitive performance, indicating preclinical disease progression.
Mesothelioma Survival Challenges Persist in the US
Despite advances in oncology, mesothelioma survival rates in the US remain low, highlighting persistent challenges in early diagnosis and effective treatment.
Diagnostic Accuracy Declines as Clinician Listening Time Shortens
Reduced clinician listening time correlates with decreased diagnostic accuracy and patient satisfaction, impacting care quality and outcomes.
Dementia Linked to Increased Suicidal Behavior Risk
Dementia is associated with an elevated risk for suicidal behavior, particularly when co-occurring with other mental health conditions.
Ultraprocessing Not Inherently Harmful, Context Matters
New perspectives suggest that the health impact of ultraprocessed foods may depend more on nutrient composition than processing level alone.
Psilocybin Effective for TRD in Real-World Trial
Psilocybin-assisted therapy (PAT) demonstrates clinical promise for treatment-resistant depression (TRD), with ongoing evaluation of its economic value.
Hydrofluoric Acid Burns: Missed Diagnoses Lead to Delayed Treatment
Hydrofluoric acid burns are frequently misdiagnosed due to non-specific initial symptoms, delaying critical calcium gluconate therapy and increasing morbidity.
Why New Alzheimer's Drugs Make Brains Bleed?
ARIA — amyloid-related imaging abnormalities — affects up to 24% of patients on anti-amyloid therapy. APOE4 genotyping, MRI monitoring protocols, severity-graded management, and the anticoagulation dilemma: a practical guide to navigating the risk.
Preventing 45 Percent Of Dementia Cases
The Lancet Commission 2024 estimates 45% of dementia is preventable. SPRINT-MIND showed 19% MCI reduction from intensive blood pressure control. FINGER showed 25% better cognitive scores with multi-domain lifestyle intervention. ACHIEVE showed 48% slowing in high-risk patients with hearing aids. The evidence is here — we walk through it.
The Amyloid Hypothesis, Finally Validated?
After two decades of high-profile failures, lecanemab and donanemab have produced the first positive phase 3 trials in Alzheimer's disease. We examine the CLARITY-AD and TRAILBLAZER-ALZ 2 data, the clinical meaningfulness debate, and what the approvals actually mean at the bedside.
Targeting Tau Inflammation And Alzheimer's Metabolism
Amyloid clearance is only one part of the Alzheimer's story. Why tau remains the closer correlate of cognitive decline, what the TREM2 biology tells us about microglia, what the GLP-1 signal means, and how platform trials are moving toward multi-target combination therapy.
Dexamethasone Offers No Benefit in Headache After Occipital Nerve Block
Adding dexamethasone to greater occipital nerve blocks does not improve headache intensity or duration, according to recent clinical evidence.