Olaparib: Why HRD in breast and ovarian cancer goes beyond BRCA
Olaparib demonstrated activity in HR-deficient metastatic triple-negative breast cancer and platinum-sensitive relapsed ovarian cancer without germline BRCA1/2 mutations.
Salivary gland cancer: Is HER2-low the new HER2-positive?
Trastuzumab rezetecan demonstrated antitumor activity in advanced salivary gland carcinoma, particularly in HER2-high disease, with a 50% objective response rate.
Multicancer tests: Can we screen without knowing the outcome?
An FDA panel recently reviewed multicancer early detection tests, highlighting significant data gaps regarding their clinical utility and impact on patient outcomes.
Multicancer early detection: Can we screen for what we can't treat?
Breast cancer home injections: Convenient for patients, complex for insurers
Brain metastases: Why less radiation, more often, improves outcomes
Lung cancer in never smokers: The 60x risk factor you might be missing
Chemo hair loss: Why some patients feel it more deeply
Why are we still treating cancer prevention as adjunctive care?
Seladelpar and Elafibranor: The Second-Line Options for PBC After Ursodeoxycholic Acid Fails
Seladelpar and elafibranor offer new therapeutic avenues for primary biliary cholangitis patients with inadequate response to ursodeoxycholic acid.
Why primary sclerosing cholangitis remains a therapeutic graveyard
Despite numerous attempts, no disease-modifying therapy has succeeded in primary sclerosing cholangitis, leaving transplant as the only definitive treatment.
MASH: Why diabetes management now demands a liver-first approach?
Emerging liver-directed approaches for moderate to advanced MASH are reshaping treatment paradigms, with significant implications for diabetes specialists managing metabolic dysfunction.
ACLF: Why G-CSF works for some, but fails others
Cholangiocarcinoma Surveillance: What Interval, What Modality in PSC?
Pruritus in primary biliary cholangitis: the symptom that drives quality of life
Seladelpar and elafibranor: second-line options for PBC
Liver disease: Is coffee a daily dose of prevention?
Chronic hepatitis B: Is PD-1 blockade the key to T-cell revival?
A scientific first is approved for sickle cell disease; understanding the path to scale is now critical.
R-CHOP has been standard of care for 20 years. frontMIND may be the beginning of the end
An epidemiological shift in T2D is reshaping drug development and market access for oncology and metabolic portfolios.
The most resistant cancer is finally responding, and the pipeline is accelerating
Lecanemab and donanemab are approved. The harder question is who gets them and how
Hypertension: Do shorter wall squats work as well for older women?
Isometric wall squats reduced blood pressure in older women with hypertension, but a higher dose did not offer superior postexercise hypotension.
Tactical athletes need more than a sports physical
New recommendations address cardiovascular screening and management for tactical athletes, focusing on unique physiological demands and risk factors in this population.
The 2026 ADA/EASD consensus: Why early SGLT2/GLP-1 works
The 2026 ADA and EASD consensus advocates early SGLT2 inhibitor or GLP-1-based therapy, potentially from diagnosis, and makes weight a formal treatment target.
Low-carb diets in kids with type 1 diabetes: safe, but not standard?
In 45,569 children, very low carbohydrate diets were not linked to poorer growth, severe hypoglycaemia or ketoacidosis, though the evidence remains observational.
Fibromyalgia: Is the pain real if the tissue damage isn't?
Fibromyalgia is increasingly understood as a central nervous system disorder, not a peripheral tissue disease, challenging traditional diagnostic approaches.
Spike sorting: Is your 'black box' holding back neural insights?
Understanding the intricate process of spike sorting is essential for interpreting neural recordings. A modular approach promises greater transparency and adaptability in this complex analytical task.
Parkinson's cognitive decline: Is Juvmo the answer we overlooked?
The FDA approved Juvmo for adults with Parkinson's disease, targeting cognitive decline, a common and debilitating aspect of the condition.
Brexpiprazole for Alzheimer's agitation: Antidepressants don't change efficacy
Lifelong odor sensitivity: What early exposure means for your patients?
Tau: Why its 'knockout' effect is a clue to Alzheimer's
Routine childhood vaccines: Less coverage means more than just infections
Evolocumab: Is LDL-C reduction finally translating to lives saved?
Peripheral arterial disease: Why early detection still eludes us
GLP-1s: Is eligibility missing half your high-risk patients?
LAA occlusion: Less bleeding, but is stroke risk truly equal?
Beyond diagnosis: ECG waveforms predict MI-E treatment response
Rethinking xylitol: Is this 'healthy' sugar substitute a cardiac threat?
Marathon running with type 1 diabetes: Is it finally safe?
Amylin plus tirzepatide: Is 23% weight loss the new benchmark?
Survodutide: Is 9.8% weight loss enough for its GI cost?
Rotavirus vaccine and T1D: Is an 11% rise cause for alarm?
Bariatric surgery: The hidden hernia risk you're missing
CBL-514: Is visceral fat reduction the real story?
Sjögren's Disease: Early Damage Often Present at Diagnosis
Get the full storySjögren's Disease: New Therapies Target Underlying Immune Pathways
Get the full storyCrystal Arthritis: The ICU Fever You Keep Missing
Get the full storyWhen Joint Pain Strikes: Distinguishing Gout, Pseudogout, and Septic Arthritis
Get the full storyCalcium Pyrophosphate Deposition Disease: What the 2023 Criteria Enable
Get the full storyAntiphospholipid Antibody Testing: When to Trust the Results
Get the full storyWhy triple-positive antiphospholipid syndrome defies direct oral anticoagulants
Get the full storyStatin-associated myopathy: rare, real, and reversible?
Get the full storyMyositis-Specific Autoantibodies: Predicting Prognosis and Guiding Screening
Get the full storyAutologous Stem Cell Transplant in Scleroderma: Who Justifies the Risk?
Get the full story
Idiopathic Pulmonary FibrosisIPF: Why new therapies are still missing the mark
Get the full storyAlpha-1 Antitrypsin Deficiency: Why fragmented care costs lives
Get the full storyRespiratory care: Why neurology's long-acting therapies could be key
Get the full storyRethink PDE inhibition in COPD: Not all isoforms are equal
Get the full storySevere asthma: Why targeted therapies miss some Type 2 patients
Get the full storyPH-ILD: Why current vasodilators fall short, and what's next
Get the full storyBeyond rescue inhalers: What really keeps COPD patients out of hospital?
Get the full storyCOPD exercise limits: Is your oxygen therapy doing enough?
Get the full storyChronic lung disease: Why early diagnosis still isn't enough
Get the full storySleep Apnea: Why AHI Misses What Matters Most
Get the full story
Clostridioides difficileNatural spring water: Why 'pure' can still mean peril for patients
Get the full storyFoodborne outbreaks: Are we seeing more, or just reporting better?
Get the full storyRSV and COVID-19 vaccines: Why are we still underestimating their impact?
Get the full storyBixlenvo: Is the smallest HIV pill also the biggest advantage?
Get the full storyDolutegravir for HIV in newborns: A new option for an urgent need
Get the full storyUndiagnosed TB deaths in England highlight diagnostic failures
Get the full storySerology and PCR: Optimising COVID-19 Episode Identification
Get the full storyAsymptomatic bacteriuria: The treatment decision that fuels antibiotic resistance
Get the full storyWhy syphilis rates keep climbing in high-income countries
Get the full storyCongenital Syphilis: The Missed Opportunities Behind Rising Case Counts
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Acne VulgarisEpithelial health: more than a symptom of chronic inflammation?
Get the full storyDermatomyositis: Why an oral JAK inhibitor changes everything
Get the full storyCould immune system modulation be the next frontier in skincare?
Get the full storyWhy rosacea flushing resists standard therapy: a neurovascular disconnect
Get the full storyMatching rosacea therapy to dominant features: A phenotype-led approach
Get the full storyDoes targeting Demodex mites improve rosacea outcomes?
Get the full storyAntihistamine-refractory urticaria: when standard care falls short
Get the full storyChronic Urticaria: The Diagnostic Tests That Rarely Help
Get the full storyRemibrutinib: A New BTK Inhibitor for Chronic Urticaria Beyond Omalizumab
Get the full storyAlopecia Areata: What happens when patients stop treatment?
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Survodutide: Is 9.8% weight loss enough for its GI cost?
SYNCHRONIZE-2 in NEJM: survodutide 6.0 mg cut weight 9.8% versus 3.9% on placebo over 76 weeks in type 2 diabetes, but about 1 in 4 stopped treatment.
The 2026 ADA/EASD consensus: Why early SGLT2/GLP-1 works
The 2026 ADA and EASD consensus advocates early SGLT2 inhibitor or GLP-1-based therapy, potentially from diagnosis, and makes weight a formal treatment target.
GLP-1 weight loss: Is muscle loss inevitable?
Adding trevogrumab to semaglutide cut lean mass loss roughly in half and preserved up to 72% of thigh muscle volume, phase 2 data show.
Amylin plus tirzepatide: Is 23% weight loss the new benchmark?
Eloralintide combined with tirzepatide cut body weight by up to 23.3% at 48 weeks in adults with obesity and type 2 diabetes, phase 2b data show.
Type 1 diabetes screening: Why one protocol worked across 8 nations
EDENT1FI tested 140,568 young people and found early-stage type 1 diabetes in about 1 in 45 with a relative and 1 in 350 without, across 8 countries.
CBL-514: Is visceral fat reduction the real story?
CBL-514 reduced visceral fat volume by 10.45% versus a 11.76% rise on placebo in a 40-person MRI subgroup, but the weight regain claim rests on rat data.
Oral GLP-1: Is it time to rethink insulin glargine for T2D?
Orforglipron matched insulin glargine on cardiovascular safety and beat it on weight, HbA1c and hypoglycaemia, ACHIEVE-4 trial data show.
Diabetes prevalence: Is your diagnostic method missing the truth?
Four decades of gold-standard glucose tolerance testing show Mauritius is the first country to document a sustained fall in type 2 diabetes prevalence.
Low-carb diets in kids with type 1 diabetes: safe, but not standard?
In 45,569 children, very low carbohydrate diets were not linked to poorer growth, severe hypoglycaemia or ketoacidosis, though the evidence remains observational.
Early type 2 diabetes: Is remission the new normal for young adults?
A low-energy diet paired with structured exercise achieved diabetes remission in 54% of adults with early-onset type 2 diabetes, versus 4% with usual care.
Rotavirus vaccine and T1D: Is an 11% rise cause for alarm?
Type 1 diabetes incidence in Norwegian children rose 11% after rotavirus vaccination began, but similar rises followed unrelated vaccine changes.
GLP-1s for young T2D: Are we underestimating their real-world impact?
Real-world registry data from Germany, Austria and Luxembourg show GLP-1 drug use in young people with type 2 diabetes rose from 6.3% to 27.2% between 2019 and 2025, with real improvements in weight and glucose control.
GLP-1 intolerance: Petrelintide offers a new path to weight loss?
Weekly petrelintide produced up to 10.7% weight loss with 20% nausea, well below the rates typically seen with GLP-1 drugs, phase 2 data show.
GLP-1 drugs work better for women, yet most can't get them. Why?
Women lose more weight than men on GLP-1 drugs, but 80% of eligible adults live in countries where retail prices put treatment out of reach.
Why are women who switch birth control more likely to start semaglutide?
Danish women who used three or more types of hormonal contraception were about twice as likely to later start semaglutide, a 250,000-person study finds.
GLP-1s in pregnancy: Reassuring data, one unresolved signal
A meta-analysis of over 43,000 women found no rise in birth defects or preterm birth with first-trimester GLP-1 exposure, but a pregnancy-loss signal remains unresolved.
Can a 20-second voice recording really flag type 2 diabetes?
A validation study of more than 7,000 UK adults finds an AI model trained on 20-second speech recordings detects type 2 diabetes with accuracy approaching QDiabetes, and the model's risk scores tracked real HbA1c blood results.
Why stable blood pressure isn't always stable: A hidden stroke risk?
A UK Biobank study of 57,611 people finds visit-to-visit blood pressure variability predicts mortality and stroke even after accounting for average blood pressure, and the combination of high variability and type 2 diabetes carries close to three times the mortality risk.
Semaglutide and pancreatic cancer: Is the risk real?
A regulator-mandated safety study using nationwide registry data from Denmark, Sweden and Norway found no increased pancreatic cancer risk with semaglutide compared to other glucose-lowering drugs, with no dose or duration effect.
Retatrutide: Why diabetes patients may finally match weight loss
Retatrutide cut body weight by up to 18.8% and HbA1c by 1.45 points in adults with type 2 diabetes and obesity, phase 3 data show.
Why diabetes risk isn't just lifestyle, but where you live
Canadian researchers tracking almost 2 million adults over up to 21 years find people who moved from a high-poverty to a lower-poverty neighbourhood developed type 2 diabetes at a 57% lower rate than those who stayed put.
After T2D, CKD and HF aren't separate risks. Here's why
A 1.6 million-patient analysis maps how chronic kidney disease and heart failure actually unfold after a type 2 diabetes diagnosis, and what happens once the first complication has already arrived.
Ultra-processed foods: Exercise can cut type 2 diabetes risk
A UK Biobank analysis combining diet records, wearable activity data and genetic risk scores finds that meeting WHO activity guidelines meaningfully lowers type 2 diabetes risk, even for people with high genetic susceptibility and high ultra-processed food intake.
Orforglipron: Does menopausal status really matter for weight loss?
A post-hoc subgroup analysis of the ATTAIN-1 and ATTAIN-2 trials finds orforglipron's weight-loss and waist-circumference benefits held up whether women were pre-, peri- or post-menopausal.
GLP-1s: Is eligibility missing half your high-risk patients?
A 313,000-person Danish and UK analysis finds people with a BMI of 25-26.9, currently ineligible for GLP-1 receptor agonists, have coronary heart disease risk matching those who do qualify, if they also carry elevated remnant cholesterol or inflammation.
Type 2 diabetes: CGM cuts mortality, but how?
A target trial emulation of nearly 28,000 US patients finds people with type 2 diabetes on basal insulin who started continuous glucose monitoring had 44% lower one-year mortality and fewer cardiovascular events than matched non-users.
Not all red meat is equal for type 2 diabetes risk
A 90,000-person French cohort study finds Neu5Gc, a non-human sugar concentrated in red meat, is linked to a 63% higher type 2 diabetes risk at the highest versus lowest intake, with a dose-response pattern and only partial mediation through weight gain.
Type 2 diabetes: Gut bugs predict risk before blood sugar rises?
A study of more than 200,000 people identifies 789 gut bacterial species linked to type 2 diabetes, with the same signature detectable in people with normal blood sugar who show early signs of insulin resistance after meals.
Exam stress, blood sugar: a clinical paradox?
A small continuous-glucose-monitoring study of 22 healthy medical students finds glucose levels rose in the days before an exam and peaked on exam day, raising questions about the cumulative metabolic cost of repeated academic stress.
Neurodiversity in type 2 diabetes isn't evenly spread by age
A cross-sectional analysis of 3.4 million matched pairs finds neurodiversity prevalence in type 2 diabetes is heavily concentrated in the youngest patients, with autism four times more common and ADHD twice as common at the earliest ages of diagnosis.
Metformin for prediabetes: Is early use the new standard?
Early initiation of metformin can delay the onset of type 2 diabetes in high-risk individuals, reducing the long-term burden of metabolic disease. This strategy aligns with established guidelines for prediabetes management.
Is your diabetes care missing the full metabolic picture?
New technologies are moving beyond simple glucose monitoring to integrate additional biomarkers, offering a more comprehensive view of metabolic health in diabetes management.
MASH: Why diabetes management now demands a liver-first approach?
Emerging liver-directed approaches for moderate to advanced MASH are reshaping treatment paradigms, with significant implications for diabetes specialists managing metabolic dysfunction.
Rethinking GLP-1s: Beyond diabetes, a new cardiometabolic role
GLP-1-based therapies are redefining the management of chronic metabolic diseases, moving beyond glucose control to address broader cardiometabolic risk.
Amylin analogues: The missing piece in cardiometabolic care?
Amylin analogues are emerging as a potential new class of therapy for cardiometabolic disease, building on established physiological roles in glucose homeostasis and satiety.
Predictive CGM: Stop chasing nocturnal lows, prevent them
Predictive continuous glucose monitoring (CGM) technology offers a new approach to managing nocturnal hypoglycaemia, providing real-time alerts that allow for proactive intervention. This technology aims to reduce the fear and clinical burden associated with overnight glucose fluctuations in patients with diabetes.
Type 2 diabetes: What if insulin only needed to be weekly?
Insulin efsitora alfa represents a shift towards once-weekly basal insulin, aiming to simplify regimens and improve adherence for patients with type 2 diabetes.
Automated insulin delivery: Why pregnancy makes glucose control harder
Automated insulin delivery systems offer improved glucose control, but pregnancy and menstrual cycle variations present unique challenges for optimal management.
Metabolic health: Why weight loss isn't enough for your patients
Metabolic health extends beyond simple weight loss, requiring a focus on underlying biological mechanisms that drive dysfunction. Effective interventions target insulin resistance, inflammation, and adipocyte function.
Lipohypertrophy: It's not just cosmetic for GLP-1 patients
Suboptimal injection practices contribute to lipohypertrophy, impairing drug absorption and glycemic control in patients using insulin and GLP-1 injectables. Correct technique is essential for therapeutic efficacy.
Semaglutide: Beyond weight loss, what's the real reason it works?
Semaglutide, a GLP-1 RA, shows promise beyond obesity and diabetes, with emerging data suggesting roles in orthopedics and heart failure with preserved ejection fraction.
Type 1 diabetes: Beyond insulin, what are we missing?
Early-stage type 1 diabetes care extends beyond insulin, requiring a comprehensive approach to manage glycaemia, prevent complications, and support patient well-being.
Beyond statins: The counterintuitive path to cutting pancreatitis risk
ApoC-III inhibition with plozasiran reduced triglycerides by 53%-58% and showed a borderline 17% reduction in pancreatitis events in severe hypertriglyceridemia.
Type 1 diabetes: Why managing insulin isn't enough anymore
Teplizumab represents a significant step in autoimmune type 1 diabetes management, moving beyond insulin replacement to target disease progression itself. Its mechanism offers a new approach to preserving beta-cell function.
Beyond HbA1c: What integrated diabetes care really means for organs
Managing diabetes extends beyond glucose control, requiring a holistic approach to prevent heart, kidney, and liver complications.
Type 2 diabetes: Is early control a cancer shield or a red herring?
Poor glycaemic control soon after type 2 diabetes diagnosis correlates with increased cancer risk, particularly for pancreatic and colorectal cancers.
CKD, T2D: Why RAASi isn't enough for cardiorenal protection?
Non-steroidal mineralocorticoid receptor antagonists offer a new therapeutic avenue for cardiorenal protection, particularly in patients with chronic kidney disease and type 2 diabetes. These agents mitigate inflammation and fibrosis, addressing residual risk beyond traditional renin-angiotensin-aldosterone system inhibition.
Sex and hypoglycaemia in type 1 diabetes: what CGM data now show
Across 110 events in 12 adults with type 1 diabetes, sexual intercourse caused no clinically significant hypoglycaemia. Glucose moved in both directions, shaped by the starting level, body mass index and time of day.
Why CGM readings drift during a marathon in type 1 diabetes
In a real marathon, CGM error reached 36.6% to 43.1%, several times the figures seen in short laboratory exercise tests. Runners with type 1 diabetes finished as fast as controls, but a fingerstick still earns its place.
The enduring puzzle of diabetes remission after bariatric surgery
Bariatric surgery often leads to diabetes remission, but the mechanisms are complex and not solely due to weight loss. Understanding these pathways is essential for optimising patient outcomes.
Survodutide: Is 9.8% weight loss enough for its GI cost?
SYNCHRONIZE-2 in NEJM: survodutide 6.0 mg cut weight 9.8% versus 3.9% on placebo over 76 weeks in type 2 diabetes, but about 1 in 4 stopped treatment.
The 2026 ADA/EASD consensus: Why early SGLT2/GLP-1 works
The 2026 ADA and EASD consensus advocates early SGLT2 inhibitor or GLP-1-based therapy, potentially from diagnosis, and makes weight a formal treatment target.
GLP-1 weight loss: Is muscle loss inevitable?
Adding trevogrumab to semaglutide cut lean mass loss roughly in half and preserved up to 72% of thigh muscle volume, phase 2 data show.
Amylin plus tirzepatide: Is 23% weight loss the new benchmark?
Eloralintide combined with tirzepatide cut body weight by up to 23.3% at 48 weeks in adults with obesity and type 2 diabetes, phase 2b data show.
Type 1 diabetes screening: Why one protocol worked across 8 nations
EDENT1FI tested 140,568 young people and found early-stage type 1 diabetes in about 1 in 45 with a relative and 1 in 350 without, across 8 countries.
CBL-514: Is visceral fat reduction the real story?
CBL-514 reduced visceral fat volume by 10.45% versus a 11.76% rise on placebo in a 40-person MRI subgroup, but the weight regain claim rests on rat data.
Oral GLP-1: Is it time to rethink insulin glargine for T2D?
Orforglipron matched insulin glargine on cardiovascular safety and beat it on weight, HbA1c and hypoglycaemia, ACHIEVE-4 trial data show.
Diabetes prevalence: Is your diagnostic method missing the truth?
Four decades of gold-standard glucose tolerance testing show Mauritius is the first country to document a sustained fall in type 2 diabetes prevalence.
Low-carb diets in kids with type 1 diabetes: safe, but not standard?
In 45,569 children, very low carbohydrate diets were not linked to poorer growth, severe hypoglycaemia or ketoacidosis, though the evidence remains observational.
Early type 2 diabetes: Is remission the new normal for young adults?
A low-energy diet paired with structured exercise achieved diabetes remission in 54% of adults with early-onset type 2 diabetes, versus 4% with usual care.
Rotavirus vaccine and T1D: Is an 11% rise cause for alarm?
Type 1 diabetes incidence in Norwegian children rose 11% after rotavirus vaccination began, but similar rises followed unrelated vaccine changes.
GLP-1s for young T2D: Are we underestimating their real-world impact?
Real-world registry data from Germany, Austria and Luxembourg show GLP-1 drug use in young people with type 2 diabetes rose from 6.3% to 27.2% between 2019 and 2025, with real improvements in weight and glucose control.
GLP-1 intolerance: Petrelintide offers a new path to weight loss?
Weekly petrelintide produced up to 10.7% weight loss with 20% nausea, well below the rates typically seen with GLP-1 drugs, phase 2 data show.
GLP-1 drugs work better for women, yet most can't get them. Why?
Women lose more weight than men on GLP-1 drugs, but 80% of eligible adults live in countries where retail prices put treatment out of reach.
Why are women who switch birth control more likely to start semaglutide?
Danish women who used three or more types of hormonal contraception were about twice as likely to later start semaglutide, a 250,000-person study finds.
GLP-1s in pregnancy: Reassuring data, one unresolved signal
A meta-analysis of over 43,000 women found no rise in birth defects or preterm birth with first-trimester GLP-1 exposure, but a pregnancy-loss signal remains unresolved.
Can a 20-second voice recording really flag type 2 diabetes?
A validation study of more than 7,000 UK adults finds an AI model trained on 20-second speech recordings detects type 2 diabetes with accuracy approaching QDiabetes, and the model's risk scores tracked real HbA1c blood results.
Why stable blood pressure isn't always stable: A hidden stroke risk?
A UK Biobank study of 57,611 people finds visit-to-visit blood pressure variability predicts mortality and stroke even after accounting for average blood pressure, and the combination of high variability and type 2 diabetes carries close to three times the mortality risk.
Semaglutide and pancreatic cancer: Is the risk real?
A regulator-mandated safety study using nationwide registry data from Denmark, Sweden and Norway found no increased pancreatic cancer risk with semaglutide compared to other glucose-lowering drugs, with no dose or duration effect.
Retatrutide: Why diabetes patients may finally match weight loss
Retatrutide cut body weight by up to 18.8% and HbA1c by 1.45 points in adults with type 2 diabetes and obesity, phase 3 data show.
Why diabetes risk isn't just lifestyle, but where you live
Canadian researchers tracking almost 2 million adults over up to 21 years find people who moved from a high-poverty to a lower-poverty neighbourhood developed type 2 diabetes at a 57% lower rate than those who stayed put.
After T2D, CKD and HF aren't separate risks. Here's why
A 1.6 million-patient analysis maps how chronic kidney disease and heart failure actually unfold after a type 2 diabetes diagnosis, and what happens once the first complication has already arrived.
Ultra-processed foods: Exercise can cut type 2 diabetes risk
A UK Biobank analysis combining diet records, wearable activity data and genetic risk scores finds that meeting WHO activity guidelines meaningfully lowers type 2 diabetes risk, even for people with high genetic susceptibility and high ultra-processed food intake.
Orforglipron: Does menopausal status really matter for weight loss?
A post-hoc subgroup analysis of the ATTAIN-1 and ATTAIN-2 trials finds orforglipron's weight-loss and waist-circumference benefits held up whether women were pre-, peri- or post-menopausal.
GLP-1s: Is eligibility missing half your high-risk patients?
A 313,000-person Danish and UK analysis finds people with a BMI of 25-26.9, currently ineligible for GLP-1 receptor agonists, have coronary heart disease risk matching those who do qualify, if they also carry elevated remnant cholesterol or inflammation.
Type 2 diabetes: CGM cuts mortality, but how?
A target trial emulation of nearly 28,000 US patients finds people with type 2 diabetes on basal insulin who started continuous glucose monitoring had 44% lower one-year mortality and fewer cardiovascular events than matched non-users.
Not all red meat is equal for type 2 diabetes risk
A 90,000-person French cohort study finds Neu5Gc, a non-human sugar concentrated in red meat, is linked to a 63% higher type 2 diabetes risk at the highest versus lowest intake, with a dose-response pattern and only partial mediation through weight gain.
Type 2 diabetes: Gut bugs predict risk before blood sugar rises?
A study of more than 200,000 people identifies 789 gut bacterial species linked to type 2 diabetes, with the same signature detectable in people with normal blood sugar who show early signs of insulin resistance after meals.
Exam stress, blood sugar: a clinical paradox?
A small continuous-glucose-monitoring study of 22 healthy medical students finds glucose levels rose in the days before an exam and peaked on exam day, raising questions about the cumulative metabolic cost of repeated academic stress.
Neurodiversity in type 2 diabetes isn't evenly spread by age
A cross-sectional analysis of 3.4 million matched pairs finds neurodiversity prevalence in type 2 diabetes is heavily concentrated in the youngest patients, with autism four times more common and ADHD twice as common at the earliest ages of diagnosis.
Metformin for prediabetes: Is early use the new standard?
Early initiation of metformin can delay the onset of type 2 diabetes in high-risk individuals, reducing the long-term burden of metabolic disease. This strategy aligns with established guidelines for prediabetes management.
Is your diabetes care missing the full metabolic picture?
New technologies are moving beyond simple glucose monitoring to integrate additional biomarkers, offering a more comprehensive view of metabolic health in diabetes management.
MASH: Why diabetes management now demands a liver-first approach?
Emerging liver-directed approaches for moderate to advanced MASH are reshaping treatment paradigms, with significant implications for diabetes specialists managing metabolic dysfunction.
Rethinking GLP-1s: Beyond diabetes, a new cardiometabolic role
GLP-1-based therapies are redefining the management of chronic metabolic diseases, moving beyond glucose control to address broader cardiometabolic risk.
Amylin analogues: The missing piece in cardiometabolic care?
Amylin analogues are emerging as a potential new class of therapy for cardiometabolic disease, building on established physiological roles in glucose homeostasis and satiety.
Predictive CGM: Stop chasing nocturnal lows, prevent them
Predictive continuous glucose monitoring (CGM) technology offers a new approach to managing nocturnal hypoglycaemia, providing real-time alerts that allow for proactive intervention. This technology aims to reduce the fear and clinical burden associated with overnight glucose fluctuations in patients with diabetes.
Type 2 diabetes: What if insulin only needed to be weekly?
Insulin efsitora alfa represents a shift towards once-weekly basal insulin, aiming to simplify regimens and improve adherence for patients with type 2 diabetes.
Automated insulin delivery: Why pregnancy makes glucose control harder
Automated insulin delivery systems offer improved glucose control, but pregnancy and menstrual cycle variations present unique challenges for optimal management.
Metabolic health: Why weight loss isn't enough for your patients
Metabolic health extends beyond simple weight loss, requiring a focus on underlying biological mechanisms that drive dysfunction. Effective interventions target insulin resistance, inflammation, and adipocyte function.
Lipohypertrophy: It's not just cosmetic for GLP-1 patients
Suboptimal injection practices contribute to lipohypertrophy, impairing drug absorption and glycemic control in patients using insulin and GLP-1 injectables. Correct technique is essential for therapeutic efficacy.
Semaglutide: Beyond weight loss, what's the real reason it works?
Semaglutide, a GLP-1 RA, shows promise beyond obesity and diabetes, with emerging data suggesting roles in orthopedics and heart failure with preserved ejection fraction.
Type 1 diabetes: Beyond insulin, what are we missing?
Early-stage type 1 diabetes care extends beyond insulin, requiring a comprehensive approach to manage glycaemia, prevent complications, and support patient well-being.
Beyond statins: The counterintuitive path to cutting pancreatitis risk
ApoC-III inhibition with plozasiran reduced triglycerides by 53%-58% and showed a borderline 17% reduction in pancreatitis events in severe hypertriglyceridemia.
Type 1 diabetes: Why managing insulin isn't enough anymore
Teplizumab represents a significant step in autoimmune type 1 diabetes management, moving beyond insulin replacement to target disease progression itself. Its mechanism offers a new approach to preserving beta-cell function.
Beyond HbA1c: What integrated diabetes care really means for organs
Managing diabetes extends beyond glucose control, requiring a holistic approach to prevent heart, kidney, and liver complications.
Type 2 diabetes: Is early control a cancer shield or a red herring?
Poor glycaemic control soon after type 2 diabetes diagnosis correlates with increased cancer risk, particularly for pancreatic and colorectal cancers.
CKD, T2D: Why RAASi isn't enough for cardiorenal protection?
Non-steroidal mineralocorticoid receptor antagonists offer a new therapeutic avenue for cardiorenal protection, particularly in patients with chronic kidney disease and type 2 diabetes. These agents mitigate inflammation and fibrosis, addressing residual risk beyond traditional renin-angiotensin-aldosterone system inhibition.
Sex and hypoglycaemia in type 1 diabetes: what CGM data now show
Across 110 events in 12 adults with type 1 diabetes, sexual intercourse caused no clinically significant hypoglycaemia. Glucose moved in both directions, shaped by the starting level, body mass index and time of day.
Why CGM readings drift during a marathon in type 1 diabetes
In a real marathon, CGM error reached 36.6% to 43.1%, several times the figures seen in short laboratory exercise tests. Runners with type 1 diabetes finished as fast as controls, but a fingerstick still earns its place.
The enduring puzzle of diabetes remission after bariatric surgery
Bariatric surgery often leads to diabetes remission, but the mechanisms are complex and not solely due to weight loss. Understanding these pathways is essential for optimising patient outcomes.
