Unraveling MASH: Implications for Clinical Practice
A new review in Nature Reviews Gastroenterology & Hepatology clarifies the complex interplay of metabolism, inflammation, and fibrosis in metabolic dysfunction-associated steatohepatitis (MASH). This understanding translates to practical guidance for risk stratification and patient management in primary care settings.
Do Vitamin D Supplements Improve Outcomes in Orthopedic Trauma?
Orthopedic trauma patients may experience improved fracture healing and reduced infection risk with vitamin D supplementation, suggesting a role in immune modulation. However, the existing evidence is not definitive enough to recommend universal supplementation.
Culturally Relevant Depression Screening for Chronic Care
Depression in chronic care settings often goes unaddressed due to cultural barriers. Clinicians can improve mental health support by adapting communication to respect local beliefs and idioms of distress.
Non-SCID T-Cell Lymphopenia Screening: System-Wide Cost Analysis
Newborn screening for non-SCID T-cell lymphopenia flags a significant number of infants, but the long-term clinical impact remains unclear, leading to potential over-testing and resource strain. A Swiss cohort study highlights the complexities of managing these cases, prompting a need for careful cost-benefit analysis of current screening protocols.
ALOX12B Mutations Rethinking Congenital Ichthyosis
Autosomal recessive congenital ichthyosis (ARCI) linked to ALOX12B mutations may represent a more profound systemic immune deficiency than previously appreciated. Vigilance for opportunistic infections and a lower threshold for immunological workups are warranted in these patients.
