Lorlatinib and Diabetic Ketoacidosis An Emerging Class Effect?

Patients on lorlatinib should be monitored for hyperglycemia, regardless of autoantibody status. This case raises concerns about potential metabolic toxicities of ALK inhibitors beyond what is currently recognized.

Smoking and Cataracts: A Clearer Vision of Prevention

Smoking-related cataracts contribute significantly to global vision impairment, a burden potentially reduced with aggressive smoking cessation strategies. Primary care physicians are uniquely positioned to communicate the tangible risk of vision loss to motivate patients towards quitting.

Infections in Ichthyosis: A Call for Vigilance

Patients with ALOX12B-associated autosomal recessive congenital ichthyosis face significant infectious risks beyond the skin. Clinicians should adopt proactive surveillance and management strategies, including early broad-spectrum antibiotics, to mitigate life-threatening complications.

Does Intrinsic Capacity Truly Predict Geriatric Outcomes?

Older inpatients often present with a constellation of geriatric syndromes, but predicting who will decline is challenging. This study suggests that assessing multiple domains of intrinsic capacity might offer some predictive value, though the effect sizes raise questions.

Extended Reality for Congenital Heart Defect Education

Visualizing complex congenital heart defects (CHDs) remains a challenge for both families and trainees. Extended reality (XR) offers a promising solution to improve understanding and procedural planning, potentially improving outcomes in this vulnerable population.