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The Life Science Feed
Podcast
Deep dives with clinicians, researchers, and industry leaders.
All episodesBTK Inhibitors in CLL: Evolving Landscape and Sequential Strategies
The management of chronic lymphocytic leukemia (CLL) with BTK inhibitors is evolving, necessitating careful consideration of treatment sequencing and resistance mechanisms.
Myasthenia Gravis in Pregnancy: Exacerbations Common in Peripartum
Myasthenia gravis (MG) in pregnancy presents diagnostic and management challenges, with exacerbations common in the first trimester and postpartum period.
Yoga Reduces Insomnia, Fatigue, Anxiety in Cancer Survivors
A new study presented at ASCO 2026 demonstrates yoga significantly improves insomnia, fatigue, and anxiety in cancer survivors.
Epigenetic Modifications Link Genes to Health Outcomes
Scientists link genetics to health through epigenetic modifications, specifically DNA methylation and histone deacetylases, influencing disease.
Biologics Offer Targeted Efficacy in Psoriasis Management
Biologic therapies have significantly advanced psoriasis treatment by targeting specific immune pathways, offering improved outcomes for patients.
CAR T-Cell Therapy Shows Efficacy in Refractory Autoimmune Disease
CAR T-cell therapy, traditionally for cancer, demonstrates potential in severe autoimmune conditions, offering a new therapeutic avenue.
Amyloid Therapies Show Limited Cognitive Benefit in Alzheimer's
Amyloid-beta targeting therapies for Alzheimer's disease demonstrate modest effects on cognitive decline, with clinical significance remaining uncertain.
Normal Flatus Frequency: Up to 25 Episodes Daily Considered Typical
Understanding normal flatus frequency is essential for distinguishing physiological gas from symptoms of gastrointestinal pathology. Up to 25 episodes per day is typical.
Stay ahead in
Life Science.
ctDNA Predicts Relapse in Early Cancer, but Clinical Action Remains Unclear
Circulating tumour DNA (ctDNA) detection post-surgery predicts relapse in early-stage cancer, but evidence for adjuvant therapy escalation based solely on ctDNA is lacking.
PROTEUS Trial: Neoadjuvant Apalutamide Plus ADT in High-Risk Prostate Cancer
The PROTEUS trial investigated neoadjuvant apalutamide plus ADT for high-risk localised prostate cancer, showing improved pathologic complete response rates.
CAR-T Therapy Versus Bispecific Antibodies
The next phase of CAR-T addresses its biggest limitations: off-the-shelf allogeneic products, in vivo gene delivery, and bispecific antibodies that redirect T cells without any gene engineering. Sarah Mitchell and James Carter explore where the technology is going - and what blood cancer management looks like by 2030.
Small Molecules VS CAR-T In CLL
23 minMoving CAR-T To Earlier Myeloma Lines
24 minCAR-T Masterstroke Or Biological Chaos?
22 minDoctor-Patient Communication Improves Treatment Acceptance in Cancer
6 min readTile Radiation for Large Brain Mets: A New Approach at ASCO 2026
6 min readMore Breast Cancer Patients Can Skip Axillary Dissection
6 min read
Alcohol and Sugar: A Dual Metabolic Challenge for Patients
Patients consuming alcohol and high-sugar diets face a compounded metabolic risk, impacting liver function and glucose regulation. Clinicians must address both factors.
EASL Congress 2026: Key Trials to Watch in Liver Disease Management
EASL Congress 2026 will feature pivotal trials in NAFLD/NASH, HBV, and HCC, potentially reshaping current treatment paradigms.
Variceal Bleeding Management: EASL 2026 Skills Centre Focuses on Endoscopic and Pharmacological Strategies
EASL 2026 Skills Learning Centre will address variceal bleeding, highlighting current evidence for endoscopic and pharmacological interventions.
EASL 2026: Liver and Spleen Elastography for Fibrosis Assessment
6 min readEASL 2026 Forum: Enhancing Patient-Clinician Communication
6 min readEASL 2026: Alcohol Policy Action Needed for Liver Disease
6 min readA-TANGO Score Refines ACLF Diagnosis, Prognosis in Cirrhosis
6 min readMASLD Diagnosis Faces Barriers Despite 2024 EASL Guidelines
5 min readEASL 2026: Non-invasive Diagnostics Advance Liver Disease Staging
7 min read
Zurich Heart Surgery Scandal: Device Safety Alert Issued
A safety alert has been issued regarding cardiac devices used in Zurich, prompting concerns about patient outcomes and regulatory oversight.
Serum Potassium Concentrations Shape Heart Failure Risk
Optimal serum potassium concentrations in heart failure (HF) are unclear, with new data clarifying the safe range for HFrEF and HFpEF.
Managing Acute Heart Failure And Cardiogenic Shock
Acute decompensated heart failure drives over one million hospital admissions annually. 30-day readmission rates are 25%. When the heart cannot compensate, the tools change entirely - IV diuretics, inotropes, mechanical circulatory support. Sarah Mitchell and James Carter cover ADHF management, cardiogenic shock, and how to prevent the revolving door.
Semaglutide For Obese Heart Failure Patients
21 minDiabetes Drugs For Stiff Heart Failure
21 minHow Four Drugs Beat Heart Failure
22 minTricuspid Valve Surgery Benefits Adults with Systemic Right Ventricle
6 min readDual Plane Block May Cut Opioid Use After Bypass Surgery
6 min readPAHO's HEARTS 2.0 Outlines 38-Step Pathway for Cardio-Renal Care
6 min read
Acupuncture Reduces Insulin Needs in Type 2 Diabetes
Acupuncture, an ancient Chinese therapy, has demonstrated efficacy in reducing insulin requirements for patients with type 2 diabetes.
Orforglipron Phase 3 Trials Show Efficacy in T2D Management
Oral GLP-1 receptor agonist orforglipron demonstrates significant reductions in HbA1c and body weight in Phase 3 trials for type 2 diabetes.
Strategies Emerge to Mitigate Post-GLP-1 Weight Regain
Weight regain following cessation of GLP-1 receptor agonist therapy presents a clinical challenge; emerging strategies focus on sustained pharmacological intervention and lifestyle modification.
Semaglutide Accepted in Scotland for CV Risk Reduction in T2D
5 min readPCOS Linked to Increased All-Cause Mortality Risk in Women
6 min readBMI Does Not Increase Complication Risk After Reverse Total Shoulder Arthroplasty
4 min read2026 Dyslipidemia Guideline: Utility in Family Medicine Assessed
5 min readThe GLP-1 Muscle Loss Dilemma
21 minThe Velvet Rope Of Weight Loss Drugs
20 min
Preventing 45 Percent Of Dementia Cases
The Lancet Commission 2024 estimates 45% of dementia is preventable. SPRINT-MIND showed 19% MCI reduction from intensive blood pressure control. FINGER showed 25% better cognitive scores with multi-domain lifestyle intervention. ACHIEVE showed 48% slowing in high-risk patients with hearing aids. The evidence is here — we walk through it.
Targeting Tau Inflammation And Alzheimer's Metabolism
Amyloid clearance is only one part of the Alzheimer's story. Why tau remains the closer correlate of cognitive decline, what the TREM2 biology tells us about microglia, what the GLP-1 signal means, and how platform trials are moving toward multi-target combination therapy.
Why New Alzheimer's Drugs Make Brains Bleed?
ARIA — amyloid-related imaging abnormalities — affects up to 24% of patients on anti-amyloid therapy. APOE4 genotyping, MRI monitoring protocols, severity-graded management, and the anticoagulation dilemma: a practical guide to navigating the risk.
The Amyloid Hypothesis, Finally Validated?
39 minCGRP Monoclonal Antibodies for Migraine Linked to Fracture Risk
6 min readReassuring Data for High-Efficacy MS Meds in Pregnancy
6 min readAmyloid Therapies Show Limited Cognitive Benefit in Alzheimer's
7 min readCGRP Inhibitors for Migraine: CV Safety Data Limited in High-Risk Patients
5 min readAmyloid Therapies Show Limited Cognitive Benefit in AD
4 min read
