A Systemic Approach to Atopic Dermatitis Treatment Selection
Systemic therapies for atopic dermatitis require careful patient selection and monitoring to maximize benefit and minimize risk. This case highlights the importance of considering disease severity, patient comorbidities, and prior treatment responses when choosing advanced therapies like biologics or small molecule inhibitors.
When to Doubt the Canadian Head CT Rule
Isolated rule-negative traumatic subarachnoid hemorrhage (SAH) can occur, even with a Glasgow Coma Scale of 15. Clinicians should maintain a degree of suspicion, especially in patients with high-risk mechanisms like falls or those on anticoagulants.
Lorlatinib and the Enigma of Autoantibody-Negative Diabetes
Patients on lorlatinib may develop diabetes with unusual characteristics, including the absence of typical autoantibodies. This presents a diagnostic challenge, requiring clinicians to consider drug-induced etiologies even when initial immunological markers are negative.
Infections in Ichthyosis: A Call for Vigilance
Patients with ALOX12B-associated autosomal recessive congenital ichthyosis face significant infectious risks beyond the skin. Clinicians should adopt proactive surveillance and management strategies, including early broad-spectrum antibiotics, to mitigate life-threatening complications.
Extended Reality for Congenital Heart Defect Education
Visualizing complex congenital heart defects (CHDs) remains a challenge for both families and trainees. Extended reality (XR) offers a promising solution to improve understanding and procedural planning, potentially improving outcomes in this vulnerable population.
