SGLT2 Inhibitors: Promise and Peril in Prader-Willi Syndrome?
SGLT2 inhibitors show potential for managing glycemic control in Prader-Willi Syndrome, but clinicians must be vigilant about the risk of renal complications. This necessitates careful patient selection and close monitoring of kidney function throughout treatment.
Do Condition-Specific Growth Charts Improve Care in Alagille Syndrome?
Growth charts tailored for Alagille Syndrome (ALGS) could refine the assessment of malnutrition in these children, but questions remain about their broad applicability. Clinicians should view these new charts cautiously, considering the limitations of the underlying data and the potential for misinterpretation.
ECPR Rewarming: A Case for Prolonged Resuscitation?
Hypothermia can be protective, even in the face of cardiac arrest and severe coagulopathy. This case challenges the premature termination of resuscitation efforts in severely hypothermic patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR).
Lorlatinib and New-Onset Diabetes Practical Monitoring for Oncologists
Patients on lorlatinib require vigilant monitoring for hyperglycemia and ketoacidosis, regardless of pre-existing diabetes risk factors. Proactive screening and early intervention are crucial to mitigate potential severe complications and ensure patient safety.
Unraveling MASH: Implications for Clinical Practice
A new review in Nature Reviews Gastroenterology & Hepatology clarifies the complex interplay of metabolism, inflammation, and fibrosis in metabolic dysfunction-associated steatohepatitis (MASH). This understanding translates to practical guidance for risk stratification and patient management in primary care settings.
