Will AI-ECGs Redefine Valve Disease Screening?

AI-enhanced ECGs may offer a new avenue for early detection of regurgitant valvular heart diseases. However, clinicians should be aware of the limitations and potential for both false positives and negatives.

Erythroblasts in B12 Deficiency: An Ominous Sign?

The presence of early erythroblasts on peripheral blood film in severe vitamin B12 deficiency may indicate a more profound disruption of bone marrow function than previously appreciated. Clinicians should consider aggressive intervention and vigilant monitoring in such cases, as this presentation might signal a higher risk of complications.

ECPR Rewarming: A Case for Prolonged Resuscitation?

Hypothermia can be protective, even in the face of cardiac arrest and severe coagulopathy. This case challenges the premature termination of resuscitation efforts in severely hypothermic patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR).

Berotralstat vs. Lanadelumab Safety in Angioedema Prophylaxis

For hereditary angioedema (HAE) patients, prophylactic treatment is shifting the paradigm towards a 'normal' life, but safety profiles differ significantly between oral and injectable options. Understanding these nuances is vital for tailoring treatment to individual patient needs and preferences, especially in the context of long-term management.

Navigating the Macrocytic Anemia Maze When You See Early Erythroblasts

The presence of nucleated red blood cells (NRBCs) on a peripheral blood smear in the setting of macrocytic anemia warrants prompt investigation. This finding, while rare, demands a systematic approach to differentiate between vitamin B12 deficiency, severe hemolysis, and underlying hematologic malignancies.