Research

PH-ILD: Why current vasodilators fall short, and what's next

An inhaled sGC activator is under investigation for pulmonary hypertension associated with interstitial lung disease, a condition with significant unmet need.

Beyond diagnosis: ECG waveforms predict MI-E treatment response

Electrocardiogram waveforms offer insights into myocardial infarction with epicardial coronary artery disease (MI-E) efficacy, providing a non-invasive window into myocardial health.

Sleep Apnea: Why AHI Misses What Matters Most

Traditional AHI metrics often miss the full impact of sleep apnea; hypoxic burden and specific phenotyping offer a clearer picture of patient risk and device efficacy.

Obesity hypoventilation: CPAP vs. NIV, the economic tension

Obesity hypoventilation syndrome (OHS) can be managed with either CPAP or NIV, with device choice impacting economics and operations.

Why targeting IL-33 could change how we manage COPD

Interleukin-33 plays a complex role in COPD pathogenesis, driving both inflammation and mucus production, which contributes to exacerbation risk.

Asthma: Why are we still guessing when omics can personalize care?

New reviews highlight how omics technologies and artificial intelligence are transforming asthma diagnosis, prognosis, and treatment decisions, moving beyond empirical approaches.

Long-term oxygen therapy: Are we missing the patient experience?

A new questionnaire, QuOTE, offers a simple, patient-reported method to evaluate the impact of long-term oxygen therapy on daily life. This tool provides a direct measure of patient experience, which has been historically difficult to quantify.

Pulmonary hypertension: Are we missing a key driver of vascular remodeling?

The insulin-like growth factor (IGF) family contributes to vascular remodeling and endothelial dysfunction in PAH, suggesting potential as diagnostic biomarkers and therapeutic targets.

CRRT: Is earlier liberation better for young patients?

Early liberation from continuous renal replacement therapy (CRRT) may offer benefits for younger patients, potentially reducing complications and improving outcomes.