Research

EHR-derived marker flags liver transplant recipients at high risk of early death

An EHR-based marker identifies liver transplant recipients at increased risk of 90-day mortality, offering a tool for pre-transplant risk stratification and post-operative management.

IgA nephritis in older transplant patients: a data desert for optimal care

Optimal management of IgA nephritis in older, post-transplant patients remains poorly defined due to a critical lack of dedicated research.

How lipid packing dictates caveolae stability at the plasma membrane

Lipid packing density plays a critical role in confining caveolae to the plasma membrane, influencing their stability and function in cellular processes.

ARHGAP36: A new survival predictor for neuroblastoma patients

High ARHGAP36 levels predict improved 5-year survival in neuroblastoma patients, linking FOXC1-induced expression to altered Hedgehog signaling.

Enhancer activity: The indirect chromatin modulation that reshapes gene expression

Ligand-dependent enhancer activation indirectly influences non-target promoters within the same chromatin domain, revealing a complex regulatory mechanism.

New CRISPR screen identifies key regulators of anterior neural tube closure

A novel CRISPR interference screen in human organoids identified ZIC2, SOX11, and ZNF521 as essential transcription factors governing anterior neural tube closure.

Infants move to music, but coordinated rhythm takes a year to emerge

Infants exhibit enhanced auditory responses to music from 3 months, but complex, structured movement patterns to music only emerge by 12 months.

Prime editing in zebrafish: a precise path to gene modification?

Prime editing, a refined CRISPR/Cas9 technology, enables precise DNA insertions and substitutions in zebrafish, with nuclease-based PEn achieving up to 27.3% precise insertion.

When ribosomes pause at stop codons, protein integrity hangs in the balance

Ribosome pausing at stop codons varies by sequence and tissue, influencing protein C-terminal integrity and potentially leading to heterogeneous protein extensions.