Neurology

Tau: Why its 'knockout' effect is a clue to Alzheimer's

Tau hyperphosphorylation impairs cooperative binding to microtubules and disrupts lysosome trafficking in neurons, mimicking tau knockout effects.

Parkinson's cognitive decline: Is Juvmo the answer we overlooked?

The FDA approved Juvmo for adults with Parkinson's disease, targeting cognitive decline, a common and debilitating aspect of the condition.

Epilepsy: Is art the missing piece in holistic patient care?

A new exhibit showcases artists living with epilepsy, aiming to reframe public perception of the condition beyond its clinical manifestations.

Spike sorting: Is your 'black box' holding back neural insights?

Understanding the intricate process of spike sorting is essential for interpreting neural recordings. A modular approach promises greater transparency and adaptability in this complex analytical task.

Fibromyalgia: Is the pain real if the tissue damage isn't?

Fibromyalgia is increasingly understood as a central nervous system disorder, not a peripheral tissue disease, challenging traditional diagnostic approaches.

Routine childhood vaccines: Less coverage means more than just infections

Routine childhood vaccination coverage has stagnated globally, with persistent inequities amplified by the COVID-19 pandemic, raising concerns for future health outcomes.

Can mice learn to control their own brains? A new neurofeedback system

A real-time closed-loop neurofeedback system allowed mice to modulate cortical activity and movement, adapting to rule changes for reward acquisition.

Brexpiprazole for Alzheimer's agitation: Antidepressants don't change efficacy

A post hoc analysis found brexpiprazole reduced agitation in Alzheimer's dementia, with similar efficacy regardless of concomitant antidepressant use.

Alzheimer's blood tests: Why are unverified claims spreading so fast?

Unverified claims about a new Alzheimer's blood test are circulating online, creating confusion for patients and clinicians alike. These claims often overstate the test's diagnostic capabilities and clinical utility.