Alzheimer Disease

Tau: Why its 'knockout' effect is a clue to Alzheimer's

Tau hyperphosphorylation impairs cooperative binding to microtubules and disrupts lysosome trafficking in neurons, mimicking tau knockout effects.

Spike sorting: Is your 'black box' holding back neural insights?

Understanding the intricate process of spike sorting is essential for interpreting neural recordings. A modular approach promises greater transparency and adaptability in this complex analytical task.

Can mice learn to control their own brains? A new neurofeedback system

A real-time closed-loop neurofeedback system allowed mice to modulate cortical activity and movement, adapting to rule changes for reward acquisition.

Brexpiprazole for Alzheimer's agitation: Antidepressants don't change efficacy

A post hoc analysis found brexpiprazole reduced agitation in Alzheimer's dementia, with similar efficacy regardless of concomitant antidepressant use.

Alzheimer's blood tests: Why are unverified claims spreading so fast?

Unverified claims about a new Alzheimer's blood test are circulating online, creating confusion for patients and clinicians alike. These claims often overstate the test's diagnostic capabilities and clinical utility.

Can targeting tau slow cognitive decline in Alzheimer's disease?

Diranersen, an investigational antisense oligonucleotide, reduced tau levels and showed a corresponding slowdown in cognitive decline.

Pupil Dilation: A Window into Synesthesia's Perceptual Quality

Pupil size changes reflect the vividness and automaticity of synesthetic experiences, offering an objective measure of subjective perception.

Ecopipam for Tourette Syndrome: Did it deliver on its promise?

Ecopipam significantly reduced tic severity in Tourette syndrome patients, but its safety profile warrants careful consideration for long-term use.

Football Headers Linked to Cognitive Decline, Neurodegeneration

Repeated head impacts from football headers correlate with increased risk of cognitive impairment and neurodegenerative disease, particularly in former professional players.