Pulmonology

Postoperative pneumonia after cardiopulmonary bypass remains common and costly. In a prospective randomized proof-of-concept trial, high-dose inhaled nitric oxide was delivered perioperatively to prevent nosocomial infection. Feasibility and safety were dem...

After cardiopulmonary bypass, nosocomial pneumonia remains a frequent complication. High-dose nitric oxide was tested perioperatively as an adjunct to reduce infection via direct antimicrobial and mucociliary effects. Early signals indicate feasibility and ...

Nosocomial pneumonia remains a frequent complication after cardiopulmonary bypass. High-dose inhaled nitric oxide has antimicrobial and microcirculatory effects that could reduce early pulmonary infection. In a randomized, prospective proof-of-concept evalu...

In asthma and chronic rhinosinusitis with nasal polyps, inherited variation shapes airway inflammation. A large-scale genomic analysis reports 131 risk loci and enrichment in immune and epithelial tissues, pointing to type 2 and barrier-pathway mechanisms. ...

A large genetic analysis in asthma and nasal polyposis reports 131 loci , pointing to immune pathways and tissue-specific signals in airway biology. The findings emphasize mechanisms rooted in barrier-immune crosstalk and inflammatory signaling, underscorin...

In asthma and chronic rhinosinusitis with nasal polyps, shared immunologic mechanisms emerge as 131 loci converge on pathways spanning epithelial alarm signaling and eosinophilic inflammation. This genetic map underscores an airway continuum linking upper a...

In chronic obstructive pulmonary disease, breathlessness severity showed a clear association with reduced quality of life across a multinational sample. Using validated symptom measures, more severe dyspnea aligned with lower health status, independent of s...

In chronic obstructive pulmonary disease, higher breathlessness severity correlated with poorer health-related quality of life across diverse countries using standardized questionnaires and spirometry. Associations persisted after multivariable adjustment, ...

In chronic obstructive pulmonary disease, breathlessness severity correlated with poorer quality of life across multiple countries, independent of airflow obstruction. Using standardized symptom and health status instruments, the analysis highlights a consi...

In chronic obstructive pulmonary disease , patient-reported breathlessness reflects a core symptom mechanism linked to health-related quality of life. A new multinational analysis from BOLD reports that greater breathlessness severity aligns with lower qual...