Pulmonology

Alpha-1 Antitrypsin Deficiency: Why fragmented care costs lives

Alpha-1 antitrypsin deficiency presents as both a respiratory and hepatic disease, often leading to diagnostic delays and suboptimal management due to fragmented care.

Respiratory care: Why neurology's long-acting therapies could be key

Insights from multiple sclerosis treatment paradigms offer a framework for developing ultra-long-acting therapies in respiratory care, addressing adherence and disease progression.

Rethink PDE inhibition in COPD: Not all isoforms are equal

Phosphodiesterase (PDE) inhibitors offer therapeutic potential in COPD, but adverse effects, particularly nausea with PDE4 inhibitors and cardiovascular risks with chronic PDE3 inhibition, limit their broader application.

Severe asthma: Why targeted therapies miss some Type 2 patients

Emerging clinical insights suggest the distal airways play a more central role in Type 2 severe asthma pathophysiology than previously understood.

PH-ILD: Why current vasodilators fall short, and what's next

An inhaled sGC activator is under investigation for pulmonary hypertension associated with interstitial lung disease, a condition with significant unmet need.

Beyond rescue inhalers: What really keeps COPD patients out of hospital?

Preventing hospital admissions for COPD requires a comprehensive approach, moving beyond acute symptom management to address the underlying disease progression and comorbidities.

COPD exercise limits: Is your oxygen therapy doing enough?

High-flow humidified oxygen improved exercise endurance and reduced dyspnea in patients with advanced COPD compared to conventional low-flow oxygen.

Chronic lung disease: Why early diagnosis still isn't enough

Managing chronic lung diseases presents complex challenges, from accurate diagnosis to optimising long-term treatment strategies and addressing patient adherence.

Sleep Apnea: Why AHI Misses What Matters Most

Traditional AHI metrics often miss the full impact of sleep apnea; hypoxic burden and specific phenotyping offer a clearer picture of patient risk and device efficacy.