Rheumatology

Sjögren's Disease: Early Damage Often Present at Diagnosis

A 5-year multicentre study reveals that irreversible organ damage in Sjögren's disease frequently occurs early, with nearly half of patients showing damage at baseline. High disease activity and specific symptoms predict damage accrual across ocular, oral, ...

Sjögren's Disease: New Therapies Target Underlying Immune Pathways

Sjögren's disease lacks approved disease-modifying therapies. Recent insights into its immunopathogenesis are driving the development of targeted treatments for this chronic autoimmune disorder.

Crystal Arthritis: The ICU Fever You Keep Missing

Crystal arthritis, often overlooked in critically ill patients, frequently presents as unexplained fever in the intensive care unit. Early recognition is vital for appropriate management.

When Joint Pain Strikes: Distinguishing Gout, Pseudogout, and Septic Arthritis

Rapid differentiation of acute monoarthritis is critical, as misdiagnosis can lead to severe joint destruction or systemic sepsis.

Calcium Pyrophosphate Deposition Disease: What the 2023 Criteria Enable

New classification criteria for calcium pyrophosphate deposition disease (CPPD) offer a more precise diagnostic framework, distinguishing it from other arthropathies.

Antiphospholipid Antibody Testing: When to Trust the Results

Interpreting antiphospholipid antibody test results requires careful consideration of timing, thresholds, and repeat testing to avoid misdiagnosis and inappropriate treatment.

Why triple-positive antiphospholipid syndrome defies direct oral anticoagulants

Direct oral anticoagulants (DOACs) have consistently failed to prevent recurrent thrombotic events in patients with triple-positive antiphospholipid syndrome (APS). This subgroup requires careful consideration of traditional anticoagulation.

Statin-associated myopathy: rare, real, and reversible?

Statin-associated immune-mediated necrotising myopathy is a rare but distinct adverse event, requiring prompt diagnosis and specific immunomodulatory treatment.

Myositis-Specific Autoantibodies: Predicting Prognosis and Guiding Screening

Myositis-specific autoantibodies offer prognostic insights and direct screening strategies in dermatomyositis, influencing disease course and malignancy risk.