STAT3

Patients with peripheral artery occlusive disease (PAOD) face a high risk of limb amputation due to critical limb ischemia. This preclinical study suggests a potential benefit from CD34+ cell therapy combined with hyperbaric oxygen, but significant question...

Extended reality (XR) is poised to transform congenital heart disease (CHD) management by enhancing surgical planning and education. This technology offers personalized surgical rehearsals and improved family understanding of complex cardiac conditions.

Predictive models for infectious diseases can guide public health resource allocation. However, the return on investment for local surveillance must be carefully considered.

Nephrology practices must strategically adapt to digital transformation to improve chronic kidney disease and transplant management. Embracing artificial intelligence, machine learning, and telemedicine is essential for future success.

Women with polycystic ovary syndrome (PCOS) may benefit from a more targeted approach to diagnosis and treatment as researchers clarify the regulatory mechanisms at the 12q13.2 locus. This study offers a framework for integrating diverse genomic datasets to...

Payment reforms in primary care, while intended to improve efficiency and quality, can inadvertently create new ethical dilemmas for physicians. This case study from Croatia highlights the challenges faced by rural family practitioners adapting to a fee-for...

A novel class of antibacterial compounds, lipophosphonoxins, demonstrates broad-spectrum activity against ESKAPE pathogens by inhibiting LpxC. This could provide a new therapeutic avenue for multidrug-resistant infections, addressing a critical unmet need.

Delayed aortic dissection post-TAVI is a rare but catastrophic complication demanding heightened vigilance. This case underscores the need for rigorous follow-up imaging protocols, especially in patients with pre-existing aortic vulnerabilities.

Croatia's 2013 shift towards mixed-payment models in primary care offers a valuable, if imperfect, lesson for other nations facing rural healthcare challenges. The study suggests that capitation and performance-based incentives can stabilize rural practices...

Patients with Wiskott-Aldrich Syndrome (WAS) may benefit from a new therapeutic approach targeting the IL-6/STAT3 signaling pathway. This discovery offers a potential avenue for drug repurposing, especially considering the availability of existing IL-6 inhi...