Respiratory syncytial virus causes serious lower respiratory tract disease in older adults and in those living with chronic cardiopulmonary, metabolic, renal, and immunocompromising conditions. A recent multisociety position from Portuguese professional organizations consolidates evidence and offers actionable guidance on who to vaccinate, how to time and coadminister shots, and how to embed RSV vaccination into seasonal workflows.

This article translates those recommendations into pragmatic steps for clinics and health systems. We focus on risk stratification, scheduling and coadministration with influenza and SARS-CoV-2 vaccines, patient counseling, safety monitoring, and follow-up. Where appropriate, we highlight decision points that support shared decisions while maintaining operational simplicity during busy respiratory seasons.

In this article

For clinicians caring for adults who face recurrent winter respiratory illness, the practical question is not whether to discuss vaccination but how to implement it consistently and safely. The burden of respiratory syncytial virus in older populations is amplified by multimorbidity and the physiologic effects of immunosenescence, which blunt mucosal defenses and cellular responses. The Portuguese multisociety position aligns with international direction in recommending vaccination for adults 60 years and older and for younger adults with specified risk conditions. Implementation is most effective when tied to seasonal visit workflows, standing orders, and clear documentation of vaccine offers, administration, and deferrals.

Age 60 years and older remains the primary eligibility anchor, but risk-based vaccination should extend to adults younger than 60 who have chronic cardiopulmonary disease, metabolic disorders, renal disease, or immunocompromising conditions. Patients with chronic obstructive pulmonary disease or bronchiectasis face increased risk of severe lower respiratory outcomes during RSV seasons. Cardiovascular comorbidity matters as well, particularly those with a history of heart failure or ischemic heart disease, where viral illness may precipitate decompensation. A structured pre-visit review flagging these conditions ensures that eligible patients are identified before the encounter begins.

Not all eligible patients can be reached at once, so prioritization is critical early in the season. Clinics can focus first on adults 75 years and older, those with advanced frailty, and people with recent cardiopulmonary admissions, as they are at heightened risk of complications and prolonged recovery. Prioritizing those with limited access to care or homebound status can also reduce acute care utilization if outreach is coordinated. Standing orders and batch scheduling during high-traffic vaccine days create predictability for staff and reduce missed opportunities.

While head-to-head comparisons across products are limited, phase 3 programs have demonstrated clinically meaningful vaccine effectiveness against symptomatic RSV lower respiratory tract disease in older adults, including those with chronic conditions. Effectiveness estimates vary across seasons and populations, a reminder that immunologic and epidemiologic contexts shift. For operational planning, the convergent message is to vaccinate early in the respiratory season, especially before anticipated surges. Ongoing surveillance and pharmacovigilance will refine these estimates and inform updates to eligibility and timing.

Equitable implementation requires attention to logistical barriers, language access, transportation, and care fragmentation. Outreach should include proactive phone calls, patient portal prompts with clear action buttons, and coordination with community pharmacies to extend reach. Clinics serving rural or lower-income populations can partner with local health services to host vaccination drives at primary care hubs. Embed interpreter services and tailored educational materials so that diverse populations can engage with the decision process effectively.

Seasonal planning starts months before the first cases rise. Inventory forecasting, staff training, and documentation templates should be aligned across clinics, urgent care sites, and inpatient discharge pathways. Consider a single respiratory vaccine script in the electronic health record that cues RSV, influenza, and SARS-CoV-2 vaccine offers at check-in, with rooming staff empowered to initiate standing orders. Each element reduces friction and improves the odds that eligible adults receive vaccination that day.

In temperate climates, offering RSV vaccination in early autumn optimizes protection through the winter peak, with flexibility to vaccinate opportunistically during any visit. For patients with upcoming procedures or pulmonary rehabilitation starts, align vaccination at least one to two weeks before those events when feasible, ensuring a buffer for local reactions. For home health patients, coordinate nurse visits to coincide with other chronic care tasks to minimize intrusions. Maintain a short recall list for those who defer, with a planned follow-up outreach at two to four weeks.

The position supports coadministration with seasonal influenza and SARS-CoV-2 vaccines at the same visit, using separate anatomic sites. This approach reduces missed opportunities and is operationally efficient during high-volume clinics. For patients wary of multiple injections in one day, offer sequencing over short intervals, explaining that protection is most useful before respiratory virus circulation accelerates. Document products, lot numbers, and sites carefully to support safety monitoring and continuity of care.

Embed RSV vaccination into standard care pathways so that it is not solely a primary care task. Pulmonary clinics, cardiology follow-ups, endocrinology visits, and nephrology care provide ample opportunities to screen and vaccinate high-risk adults. For example, a patient with diabetes mellitus type 2 or chronic kidney disease can be offered vaccination when reviewing annual labs or adjusting medications. Hospital discharge planning, particularly after COPD exacerbations or heart failure admissions, should include RSV vaccination if due and no contraindications exist.

High-reliability implementation depends on strong documentation. Use discrete fields to capture eligibility reason, education provided, consent, vaccine brand, lot, and site. Quality dashboards can track uptake among adults 60 years and older, as well as among defined risk cohorts like asthma, COPD, heart failure, and diabetes. Quarterly reviews with frontline staff can identify bottlenecks, such as supply distribution or rooming workflows, and drive rapid-cycle improvements. Share performance data transparently to sustain engagement across teams.

Counseling should be straightforward, empathetic, and focused on outcomes that matter to patients: staying out of the hospital, preserving independence, and avoiding worsening of cardiopulmonary disease. Use plain language to explain that RSV is a common winter virus that can cause severe illness in older adults and those with chronic conditions. Emphasize that vaccination reduces the chance of lower respiratory tract disease and severe complications, though no vaccine offers perfect protection. Encourage questions and invite patients to voice preferences about same-day coadministration versus short-interval sequencing.

Adopt a brief, structured shared decision-making approach that covers personal risk, expected benefits, uncertainties, and logistics. For a patient with prior severe influenza or recent CHF exacerbation, discuss how viral illnesses can destabilize chronic disease and how vaccination may mitigate that risk. When preferences are mixed, offer a plan A and plan B, both of which ensure timely coverage before peak circulation. Document the decision and agree on a follow-up touchpoint if vaccination is deferred.

Most reactions are mild and self-limited: injection site pain, fatigue, low-grade fever, or myalgias that resolve in a few days. Provide anticipatory guidance about these effects and offer simple management strategies such as cold packs and acetaminophen if needed. Review red flags that warrant escalation, including new or worsening dyspnea, chest pain, high fever unresponsive to antipyretics, or signs of allergic reaction. Ensure patients know whom to contact after hours and how to access urgent evaluation if concerning symptoms arise.

Establish a clear process to capture and report adverse events, including allergylike reactions, neurologic symptoms, or unexpected clinical deterioration. Train staff to differentiate expected local reactions from events that merit formal reports and clinical review. Aggregate safety signals across the season and share lessons learned in staff huddles or quality meetings. Feedback loops between frontline teams and leadership enable prompt adjustments to counseling materials and workflows.

For immunocompromised patients, those on high-dose corticosteroids, or individuals with unstable chronic disease, tailor the conversation to clinical context. Collaborate with specialty teams when uncertainty exists about timing or potential interactions with other therapies. Patients with advanced COPD, oxygen dependence, or high-risk cardiac status may benefit from earlier-season vaccination and closer follow-up, even if the schedule deviates from routine visit cadence. Where evidence is limited, exercise prudent clinical judgment and document the rationale for timing decisions.

Close the loop by confirming documentation in the medical record and any regional immunization registries to support continuity across care settings. Use automated reminders to prompt post-visit check-ins for those who had prior vaccine hesitancy, recent illness, or deferral. At panel and system levels, analyze uptake and outcome data to refine next-season planning, including staffing, supply allocation, and outreach strategies. Continuous learning across seasons will improve patient experience and clinical outcomes while reducing avoidable strain on acute care services.

The operational principles described here align with a Portuguese multisociety position that integrates risk stratification, timing, and coadministration into seasonal care. For readers seeking the source statement, see the PubMed record of the position at this link. Local adaptation will reflect health system structures, vaccine supply, and regional epidemiology. A brief annual preseason huddle can align teams on eligibility, messaging, documentation, and reporting expectations.

In sum, the case for RSV vaccination among older and high-risk adults is strong, and the path to reliable delivery is achievable with standard tools already used for other vaccines. Focused risk identification, efficient coadministration, clear counseling, and robust documentation are the cornerstones. As pharmacovigilance and effectiveness data mature across seasons, eligibility criteria and timing may evolve, but the core operational playbook will remain stable. The payoff is fewer severe respiratory illnesses, fewer destabilizations of chronic disease, and a smoother winter for patients and the clinicians who care for them.

LSF-5467442377 | October 2025


Jameson K. Lee

Jameson K. Lee

Medical Correspondent, Virology & Immunology
Jameson Lee is a science journalist dedicated to the fields of epidemiology and immune-mediated diseases. He provides in-depth analysis on infectious disease outbreaks, dermatological advancements, and rheumatologic therapies. His reporting prioritizes public health implications and therapeutic innovation.
How to cite this article

Lee JK. Rsv vaccination in older adults: practical guidance for care. The Life Science Feed. Published November 29, 2025. Updated November 29, 2025. Accessed December 6, 2025. .

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References
  1. Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine. 2025. https://pubmed.ncbi.nlm.nih.gov/39869458/.