innovation

Patients suffering from chronic shoulder pain due to supraspinatus tendinopathy may benefit from a deeper understanding of the biophysics of shockwave therapy. This review clarifies the mechanisms of action, potentially leading to more informed treatment de...

In ST-elevation myocardial infarction, selective C-reactive protein apheresis aims to blunt ischemia-reperfusion injury by rapidly lowering circulating CRP early after reperfusion. The CRP-STEMI randomized trial evaluates feasibility, safety, and effects on...

In obesity, cortisol can amplify lipogenesis and inflammatory signaling, worsening adipose dysfunction. A saponin isolated from tea seed meal curtailed cortisol-triggered lipid build-up and pro-inflammatory mediators in human cells while preserving viabilit...

Condition-specific pathways in musculoskeletal rehabilitation reorganize triage, delivery, and follow-up to better match needs in osteoarthritis and other joint pain. By blending rapid screening, tailored exercise, and supported self-management, the model e...

In prostatic neoplasms, rectoprostatic fistula after brachytherapy reflects radiation-related tissue injury that complicates dissection and healing. A robotic-assisted approach enabled precise mobilization in irradiated planes, layered closure, and tissue p...

In adults with obesity, antibiotics can trigger gut dysbiosis. Supplementation with the human milk oligosaccharide 2'-fucosyllactose appears to promote microbial resilience after vancomycin exposure, with benefits that are transient. This mechanism-driven, ...

The AIVUS-CAA platform automates intravascular ultrasound analysis for coronary artery anomalies , generating standardized measurements and reports that could support diagnosis, risk stratification, and longitudinal follow-up. By streamlining segmentation a...

AIVUS-CAA introduces automated intravascular ultrasound processing for coronary artery anomalies , performing segmentation and quantification to standardize lumen and vessel measurements. The tool outputs reproducible metrics and anomaly descriptors designe...

The DANFLU-2 trial evaluates high-dose versus standard-dose influenza vaccination in older adults using a pragmatic, individually randomized, registry-enabled design. By embedding allocation in routine care and capturing outcomes via national registries, it...

The VICTORION-PLAQUE primary prevention trial evaluates inclisiran, an siRNA that silences hepatic PCSK9, to modify early atherosclerotic plaque in individuals without prior events or flow-limiting lesions. Dosed at day 0, month 3, then every 6 months , inc...