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The 2026 ADA/EASD consensus: Why early SGLT2/GLP-1 works

The 2026 ADA and EASD consensus advocates early SGLT2 inhibitor or GLP-1-based therapy, potentially from diagnosis, and makes weight a formal treatment target.

Survodutide: Is 9.8% weight loss enough for its GI cost?

SYNCHRONIZE-2 in NEJM: survodutide 6.0 mg cut weight 9.8% versus 3.9% on placebo over 76 weeks in type 2 diabetes, but about 1 in 4 stopped treatment.

Rotavirus vaccine and T1D: Is an 11% rise cause for alarm?

Type 1 diabetes incidence in Norwegian children rose 11% after rotavirus vaccination began, but similar rises followed unrelated vaccine changes.

Low-carb diets in kids with type 1 diabetes: safe, but not standard?

In 45,569 children, very low carbohydrate diets were not linked to poorer growth, severe hypoglycaemia or ketoacidosis, though the evidence remains observational.

Type 1 diabetes screening: Why one protocol worked across 8 nations

EDENT1FI tested 140,568 young people and found early-stage type 1 diabetes in about 1 in 45 with a relative and 1 in 350 without, across 8 countries.

CBL-514: Is visceral fat reduction the real story?

CBL-514 reduced visceral fat volume by 10.45% versus a 11.76% rise on placebo in a 40-person MRI subgroup, but the weight regain claim rests on rat data.

Amylin plus tirzepatide: Is 23% weight loss the new benchmark?

Eloralintide combined with tirzepatide cut body weight by up to 23.3% at 48 weeks in adults with obesity and type 2 diabetes, phase 2b data show.

Bariatric surgery: The hidden hernia risk you're missing

Up to 20% of bariatric surgery candidates present with pre-existing ventral hernias, a significant comorbidity often overlooked in surgical planning.

Lifelong odor sensitivity: What early exposure means for your patients?

Early-life exposure to specific odors permanently suppresses an odor processing channel in Drosophila, demonstrating lifelong changes to odor sensitivity via glial pruning.

Marathon running with type 1 diabetes: Is it finally safe?

Adults with type 1 diabetes can safely complete marathons by leveraging continuous glucose monitoring (CGM) and traditional glucometers for real-time glucose management.

Kidney stone surgery: When does ‘getting it all’ put older patients at risk?

Extended kidney stone surgery duration may increase complication rates in older adults, necessitating careful preoperative assessment and tailored procedural planning.

Brain metastases: Why less radiation, more often, improves outcomes

Multi-fraction stereotactic radiotherapy reduces local failure and radiation necrosis in resectable brain metastases compared to single-fraction approaches.

Autism and Medicaid: Why do lifespans shrink for the most vulnerable?

Individuals with autism spectrum disorder who rely on Medicaid experience reduced life expectancy compared to the general population. This disparity highlights critical gaps in healthcare access and support.

Tau: Why its 'knockout' effect is a clue to Alzheimer's

Tau hyperphosphorylation impairs cooperative binding to microtubules and disrupts lysosome trafficking in neurons, mimicking tau knockout effects.

Insulin dosing apps: Are we overcomplicating type 2 diabetes care?

An insulin dosing app has received FDA clearance for adults with type 2 diabetes, aiming to streamline basal insulin titration and improve glycemic control.

Parkinson's cognitive decline: Is Juvmo the answer we overlooked?

The FDA approved Juvmo for adults with Parkinson's disease, targeting cognitive decline, a common and debilitating aspect of the condition.

GLP-1s for young T2D: Are we underestimating their real-world impact?

Real-world registry data from Germany, Austria and Luxembourg show GLP-1 drug use in young people with type 2 diabetes rose from 6.3% to 27.2% between 2019 and 2025, with real improvements in weight and glucose control.

Early type 2 diabetes: Is remission the new normal for young adults?

A low-energy diet paired with structured exercise achieved diabetes remission in 54% of adults with early-onset type 2 diabetes, versus 4% with usual care.

GLP-1 weight loss: Is muscle loss inevitable?

Adding trevogrumab to semaglutide cut lean mass loss roughly in half and preserved up to 72% of thigh muscle volume, phase 2 data show.

Diabetes prevalence: Is your diagnostic method missing the truth?

Four decades of gold-standard glucose tolerance testing show Mauritius is the first country to document a sustained fall in type 2 diabetes prevalence.

Oral GLP-1: Is it time to rethink insulin glargine for T2D?

Orforglipron matched insulin glargine on cardiovascular safety and beat it on weight, HbA1c and hypoglycaemia, ACHIEVE-4 trial data show.

Why are women who switch birth control more likely to start semaglutide?

Danish women who used three or more types of hormonal contraception were about twice as likely to later start semaglutide, a 250,000-person study finds.

GLP-1 drugs work better for women, yet most can't get them. Why?

Women lose more weight than men on GLP-1 drugs, but 80% of eligible adults live in countries where retail prices put treatment out of reach.

GLP-1s in pregnancy: Reassuring data, one unresolved signal

A meta-analysis of over 43,000 women found no rise in birth defects or preterm birth with first-trimester GLP-1 exposure, but a pregnancy-loss signal remains unresolved.

GLP-1 intolerance: Petrelintide offers a new path to weight loss?

Weekly petrelintide produced up to 10.7% weight loss with 20% nausea, well below the rates typically seen with GLP-1 drugs, phase 2 data show.

Retatrutide: Why diabetes patients may finally match weight loss

Retatrutide cut body weight by up to 18.8% and HbA1c by 1.45 points in adults with type 2 diabetes and obesity, phase 3 data show.

Surgical goggles: Are we trading focus for more data?

Immersive goggles are emerging as a tool in surgical settings, offering potential enhancements to visualization and precision during complex procedures.

IBD: The silent years before symptoms begin

Inflammatory bowel disease may begin years before patients report symptoms, with subclinical inflammation detectable long before diagnosis.

Pregnancy complications: The hidden PAD risk factor you're missing?

Pregnancy complications like pre-eclampsia and gestational diabetes may increase a woman's long-term risk of developing peripheral artery disease. Clinicians should consider these obstetric histories when assessing cardiovascular risk.

Olaparib: Why HRD in breast and ovarian cancer goes beyond BRCA

Olaparib demonstrated activity in HR-deficient metastatic triple-negative breast cancer and platinum-sensitive relapsed ovarian cancer without germline BRCA1/2 mutations.

ATTR-CM: Is tafamidis enough, or is vutrisiran a better first step?

Vutrisiran improved survival and cardiovascular outcomes in ATTR-CM, with benefits consistent regardless of baseline tafamidis use in the HELIOS-B trial.

Evolocumab: Is LDL-C reduction finally translating to lives saved?

Evolocumab, a PCSK9 inhibitor, has demonstrated a potential to reduce the risk of death in patients at high cardiovascular risk, offering a critical addition to lipid-lowering strategies.

Perimenopause: Why your diagnostic toolkit needs an upgrade

A new clinical toolkit offers structured guidance for managing perimenopause in primary care, addressing symptoms and improving diagnostic clarity.

Natural spring water: Why 'pure' can still mean peril for patients

A recent outbreak of illness among wedding guests highlights the persistent risks of untreated water sources, even those perceived as natural and safe. Public health investigations are underway to identify the specific pathogens and prevent further spread.

Epilepsy: Is art the missing piece in holistic patient care?

A new exhibit showcases artists living with epilepsy, aiming to reframe public perception of the condition beyond its clinical manifestations.

Dichloroacetate: Why a 'slow burn' approach wins in PDCD

Longer-term treatment with sodium dichloroacetate improved motor function, reduced plasma lactate, and increased survival in children with pyruvate dehydrogenase complex deficiency.

Male Contraception: Why are options so limited, and what's next?

The World Health Organization has published target product profiles for male contraceptive methods, detailing the efficacy, safety, and user attributes required for future development.

Spike sorting: Is your 'black box' holding back neural insights?

Understanding the intricate process of spike sorting is essential for interpreting neural recordings. A modular approach promises greater transparency and adaptability in this complex analytical task.

Red light therapy: Are your patients paying for hype or help?

Red light therapy, or photobiomodulation, is gaining attention for its potential in treating photoaging and acne. Understanding its mechanisms and limitations is crucial for clinicians.

Autism 'epidemic' claims: What population data really shows

A population-based study found no evidence to support the notion of an autism 'epidemic', challenging widespread public perception.

Multicancer tests: Can we screen without knowing the outcome?

An FDA panel recently reviewed multicancer early detection tests, highlighting significant data gaps regarding their clinical utility and impact on patient outcomes.

Chronic hepatitis B: Is PD-1 blockade the key to T-cell revival?

A 24-week anti-PD-1 antibody regimen reduced HBsAg and enhanced HBV-specific T cell responses in patients with chronic hepatitis B, offering a potential functional cure strategy.

Spermidine: Is the longevity hype masking a clinical void?

Spermidine, a polyamine found in various foods, has garnered attention for potential health benefits, but clinical evidence remains largely preliminary.

Wilderness medicine: Are you ready for the next patient without a hospital?

Advanced practice clinicians gain critical skills in wilderness medicine, enhancing their ability to manage complex medical scenarios with limited resources.

Prison nursing: Balancing patient care with security demands

Nursing in prisons presents distinct ethical and practical challenges, requiring adaptation of standard clinical practices to a secure environment.

Oculomics: Why your routine eye exam is missing critical clues

Advanced imaging of the eye can detect early markers of systemic diseases like diabetes, hypertension, and neurodegenerative conditions, enabling proactive intervention.

Oral pain, fever in teens: Is it more than just a sore throat?

A teenage girl presenting with fever, severe mouth pain, and difficulty swallowing requires careful differential diagnosis to identify the underlying cause and guide appropriate management.

GHKL ATPases: The hidden switch driving critical cell functions?

Two specific Glu/Asp residues are critical for the initial steps of ATP hydrolysis in GHKL ATPases like MutL and GyrB. Their cooperative action facilitates the essential conformational changes required for energy release.