Nephrology

CRRT: Is earlier liberation better for young patients?

Early liberation from continuous renal replacement therapy (CRRT) may offer benefits for younger patients, potentially reducing complications and improving outcomes.

When to transplant, when to suppress: Age, donor, and severity in the decision

Advances in targeted therapies and immunotherapies create opportunities for conversion surgery in previously unresectable cancers.

Phosphate binders: The hidden pill burden sabotaging CKD management

Managing hyperphosphatemia in chronic kidney disease (CKD) demands strict adherence to phosphate binders, but the sheer pill burden often undermines treatment.

Tolvaptan and ADPKD: Does slowing kidney growth preserve function?

Tolvaptan slows the increase in total kidney volume in autosomal dominant polycystic kidney disease (ADPKD), but the direct translation of this effect into preserved kidney function remains a key question for clinicians.

Lupus Nephritis: How Low Can Steroid Doses Go?

Lower-dose steroid regimens in lupus nephritis are increasingly favored, balancing efficacy against the substantial burden of glucocorticoid toxicity.

Dialysis: Do we actually know the right phosphate target?

The optimal serum phosphate target for patients on dialysis remains a subject of ongoing debate, with current guidelines offering broad ranges.

The hidden cost of phosphate binders: Why adherence crumbles under pill burden

Poor adherence to phosphate binders in chronic kidney disease is a major problem, driven by the sheer number of pills patients must take daily.

Tenapanor: A non-binder approach to phosphate control in chronic kidney disease

Tenapanor offers a novel, non-binder mechanism for reducing serum phosphate in chronic kidney disease, targeting intestinal sodium-hydrogen exchanger 3.

Tolvaptan's Liver Risk: A Monitoring Burden Patients Weigh Differently

Tolvaptan's hepatotoxicity risk necessitates frequent monitoring, a burden that impacts patient adherence and quality of life differently across individuals.