sepsis

Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, affects approximately 50 million people annually with a global mortality of 20%. Timely recognition using sepsis screening tools, source control, and the Surviving Sepsis Campaign care bundles are the pillars of acute management. Novel immunomodulatory approaches targeting the immunosuppressive phase of sepsis and precision phenotyping to guide treatment are active research frontiers.