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Berberine, a natural antimicrobial, shows enhanced potency against endodontic pathogens when delivered via polymeric nanoparticles. This targeted approach could improve root canal disinfection and reduce the need for aggressive chemical treatments.
Lipophosphonoxins show promise as broad-spectrum antibacterial agents, but their potential for clinical use hinges on overcoming significant hurdles. Further in vivo studies and toxicity assessments are critical before considering human trials.