mycoses

Invasive fungal infections, including aspergillosis, candidiasis, and cryptococcosis, cause an estimated 1.5 million deaths annually, predominantly in immunocompromised hosts. Azole antifungals, echinocandins, and polyene amphotericin B form the cornerstone treatment arsenal, but azole resistance is a growing global concern. Novel antifungal agents targeting glucan and orotate transport are advancing through late-stage development.