peripheral arterial disease

Peripheral arterial disease affects over 200 million adults globally and is a marker of systemic atherosclerosis, conferring elevated cardiovascular event and limb loss risk. Antiplatelet therapy, statin treatment, smoking cessation, and supervised exercise programmes are the pillars of medical management. Revascularisation, endovascular or surgical, is indicated for symptomatic limb ischaemia, with emerging pharmacological strategies targeting limb perfusion.