crohn disease

Crohn's disease is a transmural, skip-lesion inflammatory bowel disease that can affect any segment of the gastrointestinal tract. Biologic therapies including anti-TNF agents, vedolizumab, and ustekinumab form the backbone of moderate-to-severe disease management, with rising use of combination treatment strategies. Tight monitoring, endoscopic mucosal healing targets, and emerging small molecules are reshaping therapeutic goals.