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Isolated splenic sarcoidosis poses a diagnostic puzzle, often mimicking other conditions. Clinicians must maintain a high index of suspicion and utilize biopsy when other causes of splenomegaly are ruled out.

Splenomegaly, while common, presents a diagnostic challenge that can leave clinicians grasping at straws. This case report serves as a springboard for a practical framework on evaluating splenic lesions, preventing unnecessary interventions and delays in di...

Isolated splenic sarcoidosis offers a unique, if rare, opportunity to dissect the immunological mechanisms driving systemic sarcoidosis. Further research into these cases could refine our understanding of sarcoidosis phenotypes and therapeutic strategies.