menopause

Menopause marks the permanent cessation of menstruation and is associated with oestrogen deficiency symptoms ranging from vasomotor symptoms to accelerated bone loss and cardiovascular risk change. Menopausal hormone therapy remains the most effective treatment for vasomotor and genitourinary symptoms, with an evolving benefit-risk evidence base. Novel non-hormonal options including fezolinetant, an NK3 receptor antagonist, are addressing unmet need in women who cannot or choose not to use oestrogen.