Hepatology

Cholangiocarcinoma Surveillance: What Interval, What Modality in PSC?

Annual surveillance for cholangiocarcinoma in primary sclerosing cholangitis patients should include noninvasive imaging and serum CA 19-9, according to expert recommendations.

Why primary sclerosing cholangitis remains a therapeutic graveyard

Despite numerous attempts, no disease-modifying therapy has succeeded in primary sclerosing cholangitis, leaving transplant as the only definitive treatment.

Pruritus in primary biliary cholangitis: the symptom that drives quality of life

Pruritus significantly impacts quality of life in primary biliary cholangitis, driving patient-reported outcomes and necessitating targeted management strategies.

Seladelpar and Elafibranor: The Second-Line Options for PBC After Ursodeoxycholic Acid Fails

Seladelpar and elafibranor offer new therapeutic avenues for primary biliary cholangitis patients with inadequate response to ursodeoxycholic acid.

Coffee may cut liver disease risk, related mortality

Regular coffee consumption correlates with a reduced risk of chronic liver disease and associated mortality, according to UK Biobank data.

TNF emerges as a key node in autoimmune hepatitis, trial shows

An integrative omics approach identified TNF as a central pathogenic driver in autoimmune hepatitis, with a phase IIa trial validating TNF inhibition.

EHR data flags liver transplant patients at highest risk of post-op complications

An EHR-based marker identifies liver transplant recipients at high risk for adverse post-transplant outcomes, offering a tool for early intervention and personalised care strategies.

EHR-derived marker flags liver transplant recipients at high risk of early death

An EHR-based marker identifies liver transplant recipients at increased risk of 90-day mortality, offering a tool for pre-transplant risk stratification and post-operative management.

EHR data identifies liver transplant patients at high risk of early graft loss

An EHR-based marker accurately identifies liver transplant recipients at elevated risk of early graft failure and mortality, offering a tool for improved post-transplant management.