Immunology

Severe asthma, CRSwNP: Why targeting TSLP upstream changes everything

Thymic stromal lymphopoietin (TSLP) inhibition offers a novel strategy for epithelial-driven inflammatory diseases like severe asthma and chronic rhinosinusitis with nasal polyps.

Eosinophil depletion: Why 'good enough' isn't enough anymore

Near-complete depletion of eosinophils is critical for optimal outcomes in eosinophil-driven diseases, moving beyond simple reduction to target the underlying pathogenic mechanism.

Intranasal epinephrine: Does it stack up to the intramuscular standard?

Intranasal epinephrine (neffy) achieved comparable pharmacokinetic profiles to intramuscular epinephrine in allergic rhinitis patients, suggesting a needle-free option for severe allergic reactions.

The hidden costs of a false penicillin allergy label

Mislabeling penicillin allergy drives increased healthcare costs, worse patient outcomes, and contributes to antimicrobial resistance.

Unmasking Penicillin Allergy: A Workflow for the Non-Allergist

Many patients carry an unsubstantiated penicillin allergy label, leading to suboptimal antibiotic choices. A structured delabelling workflow, implementable by generalists, can safely remove these labels.

Direct Oral Challenge: A Simpler Path to Delabeling Low-Risk Penicillin Allergies?

Direct oral challenge is noninferior to skin testing for delabeling low-risk penicillin allergies, offering a simpler approach in various clinical settings.

Allergen introduction: Has clinical practice truly shifted?

Despite updated guidelines recommending early allergen introduction, uptake in clinical practice has been slow and inconsistent, leaving many children at continued risk.

Oral Immunotherapy: Who Finishes the Course?

Patient selection for oral immunotherapy is critical, as adherence and completion rates vary significantly based on patient characteristics and disease severity.

Does single-dose HPV vaccination offer enough protection for a schedule change?

The shift to a single-dose HPV vaccine schedule hinges on immunogenicity data, raising questions about long-term efficacy compared to multi-dose regimens.