Immunology

Rhinitis isn't just a nuisance: It's a key to managing asthma and COPD

Chronic inflammatory diseases of the upper and lower airways are often comorbid, sharing underlying pathophysiological mechanisms. Integrated management is essential for optimal patient outcomes.

Severe asthma, CRSwNP: Why targeting TSLP upstream changes everything

Thymic stromal lymphopoietin (TSLP) inhibition offers a novel strategy for epithelial-driven inflammatory diseases like severe asthma and chronic rhinosinusitis with nasal polyps.

Eosinophil depletion: Why 'good enough' isn't enough anymore

Near-complete depletion of eosinophils is critical for optimal outcomes in eosinophil-driven diseases, moving beyond simple reduction to target the underlying pathogenic mechanism.

Intranasal epinephrine: Does it stack up to the intramuscular standard?

Intranasal epinephrine (neffy) achieved comparable pharmacokinetic profiles to intramuscular epinephrine in allergic rhinitis patients, suggesting a needle-free option for severe allergic reactions.

The hidden costs of a false penicillin allergy label

Mislabeling penicillin allergy drives increased healthcare costs, worse patient outcomes, and contributes to antimicrobial resistance.

Unmasking Penicillin Allergy: A Workflow for the Non-Allergist

Many patients carry an unsubstantiated penicillin allergy label, leading to suboptimal antibiotic choices. A structured delabelling workflow, implementable by generalists, can safely remove these labels.

Direct Oral Challenge: A Simpler Path to Delabeling Low-Risk Penicillin Allergies?

Direct oral challenge is noninferior to skin testing for delabeling low-risk penicillin allergies, offering a simpler approach in various clinical settings.

Allergen introduction: Has clinical practice truly shifted?

Despite updated guidelines recommending early allergen introduction, uptake in clinical practice has been slow and inconsistent, leaving many children at continued risk.

Oral Immunotherapy: Who Finishes the Course?

Patient selection for oral immunotherapy is critical, as adherence and completion rates vary significantly based on patient characteristics and disease severity.