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For hereditary angioedema (HAE) patients, prophylactic treatment is shifting the paradigm towards a 'normal' life, but safety profiles differ significantly between oral and injectable options. Understanding these nuances is vital for tailoring treatment to ...
A recent case report highlights a rare instance of anaphylaxis to dextromethorphan (DXM), a common over-the-counter cough suppressant. This raises concerns about the adequacy of current pharmacovigilance systems for OTC medications and the potential for und...
Addressing depression in chronic care settings is vital for improving patient outcomes. Culturally relevant screening programs may optimize the identification of at-risk individuals and facilitate access to appropriate mental health services.
Patients co-infected with HIV and hypertension in South Africa face significant out-of-pocket expenditures, jeopardizing treatment adherence. Integrating non-communicable disease (NCD) care into existing HIV programs is an economic imperative to alleviate p...
Infants with non-severe combined immunodeficiency (SCID) T-cell lymphopenia detected via newborn screening present a diagnostic and management challenge. This cohort study highlights the need for further prospective research to understand the long-term clin...
A novel *SPI1* mutation was identified in a Chinese patient with agammaglobulinemia, but the evidence for causality remains weak. Clinicians should be wary of attributing rare genetic variants to disease without robust functional validation and replication.
Outcomes for patients with inborn errors of immunity (IEI) have improved dramatically over the last 30 years, largely due to earlier diagnosis and advances in targeted therapies. However, significant disparities persist, highlighting the need for continued ...
Stem cell transplantation remains the definitive treatment for ZAP70 deficiency, but outcomes vary. This single-center study offers practical insights into patient selection, conditioning regimens, and post-transplant monitoring to optimize results.
Anaphylaxis following dextromethorphan is rare but can occur, requiring clinicians to maintain vigilance when patients present with acute allergic reactions. This case highlights the importance of detailed allergy workups, including skin testing, to identif...
Newborn screening for T-cell lymphopenia identifies infants with potential immune deficiencies, but many have transient or non-severe conditions. This raises questions about the long-term implications and costs of monitoring those who may never develop sign...