Disease Area

depressive disorder

Major depressive disorder affects over 280 million people globally and is a leading cause of disability-adjusted life-years. First-line pharmacotherapy with SSRIs and SNRIs combined with psychotherapy is established, while treatment-resistant depression has driven innovation, including ketamine/esketamine nasal spray, psilocybin-assisted therapy, and neuromodulation techniques. Biomarker-guided patient stratification and personalised treatment selection represent the frontier of psychiatric care.

Depressive Disorder
Childhood Maltreatment Memories: Trustworthy, Not Fabricated
New research challenges the long-held notion that memories of childhood maltreatment are inherently unreliable, affirming their consistency and clinical utility.
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10 min read
Depressive Disorder
Brief CBT Workshop Reduces Anxiety, Boosts Grit in Primary Students
A brief cognitive behavioral therapy workshop significantly reduced anxiety and improved active coping strategies and grit among primary school students in Malaysia.
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10 min read
Depressive Disorder
Congressman Kean Jr. Reveals Depression Diagnosis After Absence
Representative Tom Kean Jr. disclosed a depression diagnosis following a four-month absence from Congress, highlighting the prevalence of mental health conditions.
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7 min read
Depressive Disorder
New York's Old Boys' Clubs Offer Mental Health Buffer
Exclusive social clubs in New York City provide a structured environment that may mitigate mental health decline among members, fostering resilience through consistent social engagement and shared purpose.
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9 min read
Depressive Disorder
Involuntary Admissions: Clinician Mental Health Impact Explored
Involuntary psychiatric admissions present a significant ethical and practical challenge, with emerging evidence indicating a measurable impact on clinicians' mental health.
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11 min read
Depressive Disorder
30 US Doctors Declare Trump Mentally Unfit, Citing Public Behaviour
Thirty senior US doctors have declared former President Trump mentally unfit for office, based on observations of his public behaviour.
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7 min read
Depressive Disorder
AI's Dual Impact on UK Mental Health: Risks and Opportunities
AI presents both potential benefits and significant risks to UK mental health, requiring careful implementation and regulatory oversight.
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8 min read
Depressive Disorder
New Guidance on Suicidal Ideation Assessment and Management
Updated guidance from BMJ 2026 outlines essential strategies for assessing and managing suicidal ideation in adult patients.
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7 min read
Depressive Disorder
Poor Midlife Sleep Linked to Worse Well-Being Years Later
Insufficient sleep duration in midlife is associated with a decline in well-being and increased depressive symptoms in later life.
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8 min read
Depressive Disorder
Psilocybin Effective for TRD in Real-World Trial
Psilocybin-assisted psychotherapy demonstrates clinical efficacy in treatment-resistant depression (TRD) across real-world trials, supporting PAT as a meaningful advance over standard care.
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9 min read

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