Highlights

Tirzepatide in OSA: What SURMOUNT-OSA means for management

Tirzepatide demonstrated a reduction in the apnea-hypopnea index in patients with obstructive sleep apnea, offering a new therapeutic avenue for a condition often linked to metabolic dysfunction.

Managing chorea: balancing tetrabenazine, deutetrabenazine and psychiatric risk

Tetrabenazine and deutetrabenazine effectively reduce chorea in Huntington's disease, but clinicians must weigh their psychiatric adverse effects.

Mazdutide's Dual Agonism: A New Path for Type 2 Diabetes in Chinese Adults?

Mazdutide, a dual GLP-1 and glucagon receptor agonist, significantly reduced HbA1c and body weight in Chinese adults with type 2 diabetes compared to placebo.

Vegan and Vegetarian Diets: What They Tell Us About Eating Disorder Risk

Dietary restrictions, including vegan and vegetarian patterns, are frequently observed in individuals with eating disorders. These choices can complicate diagnosis and treatment, often masking underlying psychopathology.

Beyond cardio: Strength training is women's essential preventive health

Strength training offers substantial benefits for women across all life stages, from bone density to metabolic health and functional independence.

The Unexpected Upside: How Boredom Can Sharpen Focus and Drive Innovation

Boredom, often seen as a negative state, can actually foster creativity, improve problem-solving, and enhance self-awareness, offering unexpected cognitive benefits.

Infrared Workouts: Six Things Clinicians Should Know

Infrared workouts leverage heat to induce physiological responses, but their specific benefits beyond traditional exercise remain a subject of ongoing discussion.

Can you build strength without lifting to absolute failure?

Submaximal resistance training can elicit significant strength gains, challenging the long-held belief that pushing to muscle failure is essential for hypertrophy and power.

Four EU Nations Elevate Family Medicine to a Specialty. Will Others Follow?

Four European Union member states have formally recognized family medicine as a distinct medical specialty, a move that could reshape primary care training and delivery across the continent.

Does medical volunteering truly sharpen clinical acumen?

Medical volunteering offers exposure to diverse pathologies and resource-constrained settings, but its direct impact on clinical skill development remains a subject of debate among medical educators.

Hospitalists' Brutal Shifts: Can New Strategies Offer Real Relief?

Hospitalists face intense work demands and burnout. New approaches to scheduling, team-based care, and personal resilience may offer some mitigation.

Adipose Tissue: Beyond Quantity, A Driver of Cardiometabolic Risk?

Adipose tissue distribution and phenotype, not just total mass, shape cardiovascular risk through endocrine, paracrine, and neural pathways.

Weight loss: The 'metabolic advantage' is a myth. Here's why

Despite evolving dietary trends, the fundamental principle of caloric deficit remains central to effective weight management and metabolic health.

Stop guessing TNBC outcomes. Start with sTILs

Thymectomy does not increase long-term mortality or cancer risk at 10 years, according to a new analysis of patients with triple-negative breast cancer.

Metformin and Exercise: A Complicated Partnership in Type 2 Diabetes

The long-held assumption that metformin and exercise work synergistically in type 2 diabetes is being re-evaluated, with emerging perspectives suggesting potential interference.

Maternal RSV shot vs. infant antibody: What parents really want

Pregnant women and parents show a clear preference for maternal RSV vaccination over infant monoclonal antibody administration for RSV prevention.

Avoiding three risk factors extends life without dementia

Reducing three modifiable risk factors significantly extends the period of life lived without dementia, a new analysis indicates.

Dupilumab improves inflammation in eosinophilic gastritis, but what about symptoms?

Dupilumab significantly reduced eosinophil counts in patients with eosinophilic gastritis, addressing a key inflammatory driver of the disease.

Prostatectomy Leakage: The Long Road to Recovery

Urinary leakage after prostate surgery often improves significantly over 12 months, a critical period for patient recovery and quality of life.

The 'wellness' industry is coming for your patients' pets

The pet wellness industry is expanding rapidly, mirroring human trends with unproven supplements and alternative therapies. Clinicians should be aware of the potential for harm and the lack of regulatory oversight.

Endometrial repair: Why ALDH HI cells are the missing piece

Endometrial cells with high ALDH activity function as long-lived progenitors, critical for uterine development and regeneration, according to new research.

Cannabinoid hyperemesis: Why cannabis users self-medicate with hot showers

Cannabinoid hyperemesis syndrome presents as cyclic vomiting in chronic cannabis users, a diagnosis often delayed due to its mimicry of other conditions.

Tirzepatide's cardiovascular benefits extend beyond weight loss

Tirzepatide, a dual GIP and GLP-1 receptor agonist, demonstrates significant cardiovascular risk reduction in real-world patient populations.

Late thrombectomy for stroke: When 6 hours isn't the whole story

Mechanical thrombectomy may offer clinical benefits for acute ischemic stroke patients with large infarct cores, even when performed beyond the standard early treatment window.

The 'mental shortcuts' paradox: How heuristics lead to diagnostic errors

Clinicians often rely on heuristics, or mental shortcuts, which can lead to diagnostic and management errors when patient presentations deviate from classic textbook examples.

Retatrutide: Early access vs. unknown risks for your patients?

Expanded access for retatrutide is drawing mixed reactions from clinicians, who are balancing patient need with the limited data available outside of formal trials.

Your AI diet plans for hypertension may be doing more harm than good

Large language models consistently fail to generate adequate, evidence-based dietary recommendations for patients with hypertension.

Creatine supplementation in hemodialysis: A futile exercise?

Intradialytic creatine supplementation in hemodialysis patients showed feasibility and tolerability but lacked evidence of meaningful clinical improvement in a pilot study.

Emotional support after cancer: What works for young adults?

Educational guidance sessions and video-based group music therapy show promise in addressing the emotional strain and identity shifts faced by young cancer patients.

The hidden dangers in chemical hair relaxers your patients need to know

Chemical hair relaxers are linked to increased risks of uterine fibroids, endometriosis, and certain cancers. Clinicians should counsel patients on these potential dangers.

Pluvicto's expanded approval: What it means for advanced prostate cancer

The FDA expanded Pluvicto's approval for PSMA-positive metastatic castration-resistant prostate cancer, making it available earlier in the treatment sequence.

GLP-1s reduce inflammation in adults without diabetes

GLP-1 receptor agonists lower C-reactive protein levels in adults without diabetes, indicating a potential anti-inflammatory effect beyond glucose control.

Safe caffeine intake does not harm heart health

Established guidelines for safe caffeine intake do not pose a risk to cardiovascular health, despite the expanding market of caffeine-containing products.

Biomarkers hint at who recovers motor function after stroke

An exploratory substudy of the PRACTISE trial identified specific biomarkers linked to upper-extremity motor recovery after stroke, including neuroplasticity and inflammatory markers.

Beyond screen time: How short videos rewire dopamine pathways

The pervasive use of short-form video content raises questions about its impact on attention spans and cognitive processing, particularly in younger populations.

Shorter octreotide could ease variceal bleed burden for your patients

The optimal duration of octreotide infusion for acute esophageal variceal bleeding has been a subject of debate, with current guidelines recommending a 2-5 day course.

Prior Authorization: Why 'Fighting Back' Is Now Standard Practice

Navigating prior authorization is a significant burden for clinicians, often requiring multiple appeals to secure necessary patient care.

Lebrikizumab maintains atopic dermatitis remission for months off-therapy

Lebrikizumab monotherapy sustained deep remission in atopic dermatitis patients for up to 38 weeks after treatment cessation.

Setmelanotide curbs insatiable hunger in acquired hypothalamic obesity

Setmelanotide significantly improved body mass index, hunger, and hyperphagia symptoms in patients with acquired hypothalamic obesity, according to the TRANSCEND trial.

The Neutropenic Diet: An Unnecessary Burden for Leukemia and Transplant Patients?

A liberalized diet was noninferior to the traditional neutropenic diet for preventing major infections in patients with acute leukemia or undergoing stem-cell transplant.

Ecopipam for Tourette Syndrome: Did it deliver on its promise?

Ecopipam significantly reduced tic severity in Tourette syndrome patients, but its safety profile warrants careful consideration for long-term use.

Asciminib: A new first-line option for chronic myeloid leukemia?

Asciminib demonstrated superior efficacy and a favorable safety profile compared to investigator-selected TKIs in newly diagnosed chronic myeloid leukemia.

Interrupting immunomodulators for infection: a strategy without evidence?

Temporarily stopping immunomodulatory agents during infection in inflammatory rheumatic disease patients did not reduce severe infection or treatment failure compared to continuation.

Cholecystectomy: The definitive answer to recurrent gallstone pancreatitis?

Early cholecystectomy significantly reduces recurrent gallstone pancreatitis, aligning with guidelines often overlooked in real-world practice.

Weekly growth hormone therapy: a safer path to long-term height gains?

Weekly growth hormone therapy offers a potential alternative to daily injections, improving long-term height outcomes in children with growth hormone deficiency.

NHS waiting lists shorten, but regional disparities persist for patients

NHS waiting lists are finally shrinking across England, but access to timely care remains uneven, with some regions seeing little improvement.

IgA nephritis in older transplant patients: a data desert for optimal care

Optimal management of IgA nephritis in older, post-transplant patients remains poorly defined due to a critical lack of dedicated research.

World Cup Injuries: A Stress Test for Sports Medicine

The recent World Cup highlighted the intense physical demands on elite athletes, with a high incidence of muscle and joint injuries challenging current sports medicine practices.