Highlights

Lung cancer in never smokers: The 60x risk factor you might be missing

A specific EGFR variant significantly increases lung cancer risk in individuals who have never smoked, challenging traditional views on lung cancer etiology. This genetic predisposition highlights a critical, often overlooked, pathway to disease development.

Alzheimer's blood tests: Why are unverified claims spreading so fast?

Unverified claims about a new Alzheimer's blood test are circulating online, creating confusion for patients and clinicians alike. These claims often overstate the test's diagnostic capabilities and clinical utility.

Amylin analogues: The missing piece in cardiometabolic care?

Amylin analogues are emerging as a potential new class of therapy for cardiometabolic disease, building on established physiological roles in glucose homeostasis and satiety.

Type 2 diabetes: What if insulin only needed to be weekly?

Insulin efsitora alfa represents a shift towards once-weekly basal insulin, aiming to simplify regimens and improve adherence for patients with type 2 diabetes.

Predictive CGM: Stop chasing nocturnal lows, prevent them

Predictive continuous glucose monitoring (CGM) technology offers a new approach to managing nocturnal hypoglycaemia, providing real-time alerts that allow for proactive intervention. This technology aims to reduce the fear and clinical burden associated with overnight glucose fluctuations in patients with diabetes.

Automated insulin delivery: Why pregnancy makes glucose control harder

Automated insulin delivery systems offer improved glucose control, but pregnancy and menstrual cycle variations present unique challenges for optimal management.

Sex and hypoglycaemia in type 1 diabetes: what CGM data now show

Across 110 events in 12 adults with type 1 diabetes, sexual intercourse caused no clinically significant hypoglycaemia. Glucose moved in both directions, shaped by the starting level, body mass index and time of day.

Why CGM readings drift during a marathon in type 1 diabetes

In a real marathon, CGM error reached 36.6% to 43.1%, several times the figures seen in short laboratory exercise tests. Runners with type 1 diabetes finished as fast as controls, but a fingerstick still earns its place.

Pulmonary alveolar proteinosis: Your patients deserve better

Pulmonary alveolar proteinosis (PAP) management across Europe faces significant disparities, driven by varied access to diagnostic tools and treatment modalities. A unified approach is critical for improving patient outcomes.

Pulmonary fibrosis: Is inflammation friend or foe?

Fibrotic interstitial lung diseases involve intertwined inflammation and fibrosis, with varying contributions that demand personalized treatment approaches.

Stop missing ILD: AI reveals what the eye can't see

Integrating artificial intelligence with clinical expertise can accelerate the identification of interstitial lung disease, potentially improving patient outcomes.

Graves' disease: Why less antithyroid drug may be more

Adding L-carnitine and selenium to methimazole in Graves' disease significantly reduced antithyroid drug requirements and accelerated TRAb negativity.

Early menopause: A hidden driver of hypertension risk?

Women experiencing menopause at a younger age face an elevated risk of developing hypertension, according to observational data.

LAA occlusion: Less bleeding, but is stroke risk truly equal?

Left atrial appendage occlusion (LAAO) reduces nonprocedural bleeding in AF patients but shows no difference in stroke or mortality compared to medical therapy.

E-scooter head injuries: Why are urban trauma centers seeing more?

Head injuries are the most common and severe trauma associated with e-scooter use in inner-city settings, according to a recent study.

Your white coat isn't the authority it once was. What is?

The traditional white coat, once a universal symbol of medical authority, has seen its prominence wane in clinical settings, replaced by scrubs and the simple passage of time.

Beyond diabetes: Semaglutide's surprising signal in bipolar disorder

Semaglutide, a GLP-1 receptor agonist, shows an unexpected signal for mood stabilization in patients with bipolar disorder, raising questions about its broader therapeutic potential.

GLP-1s and hair loss: Is it the drug or the diet?

Rapid weight loss from GLP-1 receptor agonists can trigger telogen effluvium, a temporary hair shedding condition. Clinicians should counsel patients on this potential side effect and its management.

BPH: Why alpha-blockers aren't always enough

Benign prostatic hyperplasia management in primary care extends beyond initial pharmacotherapy, requiring a careful approach to diagnosis, patient selection, and advanced interventions.

Could immune system modulation be the next frontier in skincare?

Emerging research suggests that targeting immune pathways could offer novel strategies for managing chronic skin conditions, moving beyond symptomatic relief.